David Feldman

Web Site Links

• My Lab Site

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. View Full Information

Research Interests

Steroid hormones act by binding to intracellular receptors which regulate the expression of specific genes in target cells. My group is studying a number of aspects that relate molecular and cellular events of hormone action at the receptor level to clinically relevant questions. Some of the current projects are as follows:

1. Elucidation of the molecular basis of hereditary vitamin D resistant rickets, a genetic disease due to mutations in the vitamin D receptor.

2. Analysis of the endocrinologic mechanisms regulating vitamin D receptor expression and thereby modulating target organ sensitivity to the actions of vitamin D and its analogs.

3. Investigation of the role of vitamin D as a differentiating and antiproliferative agent with the potential to affect malignant cells, specifically prostate cancer.

4. Study of genetic variations in the vitamin D receptor gene and inheritance of low bone mass in relation to the development of osteoporosis.

Clinical Trials

• Development of Vitamin D as a Therapy for Breast Cancer - Phase II Recruiting
• A Phase II Trial of Calcitriol and Naproxen in Patients with Recurrent Prostate Cancer Suspended
• Calcitriol or Placebo in Men for Prostate Cancer Active Surveillance No longer recruiting

Publications

• A phase II trial of calcitriol and naproxen in recurrent prostate cancer. Srinivas S, Feldman D. Anticancer Res. 2009; 29 (9): 3605-10
• Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor. Malloy PJ, Wang J, Srivastava T, Feldman D. Mol Genet Metab. 2009
• Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment. Krishnan A, Feldman D. Endocr Relat Cancer. 2009
• Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms. Malloy PJ, Wang J, Jensen K, Feldman D. Endocrinology. 2009; 150 (11): 4950-7
• Tissue-Selective Regulation of Aromatase Expression by Calcitriol: Implications for Breast Cancer Therapy. Krishnan AV, Swami S, Peng L, Wang J, Moreno J, Feldman D. Endocrinology. 2009