Fredric Kraemer

Clinical Focus

• Endocrinology / Diabetes
• Lipid Metabolism Disorders
• Endocrinology and Metabolism

Administrative Appointments

• Associate Chief of Staff for Research and Development, VA Palo Alto Health Care System (2002 - 2007)
• Chief, Division of Endocrinology, Gerontology and Metabolism, Stanford University (2002 - present)

Honors and Awards

• Special Emphasis Research Career Award, NIH (1982-1987)
• Mellon Foundation Fellow, Stanford University (1983-1984)
• Hume Faculty Scholar, Stanford University (1984-1988)
• SmithKline Beecham Junior Faculty Award In Diabetes, SmithKline Beecham (1998)
• Stanford University Professorship in Endocrinology, Stanford University (2002)

Professional Education

Postdoctoral Advisees

Bin Dong,  Zhigang Hu,  Victor Khor,  Yihang Li,  Amar Singh,  XuDong Tang

Graduate & Fellowship Program Affiliations

• Medicine

Current Research Interests

Our research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology. Current research projects focus on the regulation of hormone sensitive lipase (HSL). HSL is an intracellular enzyme responsible for the cytosolic hydrolysis of intracellular triglyceride and cholesteryl esters. Thus, it has an important role in fat mobilization, but also in cholesterol metabolism. We are examining all aspects of the biology of HSL, including its mechanisms of action and its structure-function relationships in regard to adipose cell function and steroid hormone synthesis.

Clinical Trials

• Treatment of Psychotic Major Depression with Mifepristone Terminated

Publications

• Ablation of Vimentin Results in Defective Steroidogenesis. Shen WJ, Zaidi SK, Patel S, Cortez Y, Ueno M, Azhar R, Azhar S, Kraemer FB. Endocrinology. 2012
• Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes. Liu LF, Shen WJ, Ueno M, Patel S, Kraemer FB. BMC Genomics. 2011: 12 212
• Evidence for protein-mediated fatty acid efflux by adipocytes. Henkin AH, Ortegon AM, Cho S, Shen WJ, Falcon A, Kraemer FB, Lee SJ, Stahl A. Acta Physiol (Oxf). 2011
• Hormone-sensitive lipase modulates adipose metabolism through PPARγ. Shen WJ, Yu Z, Patel S, Jue D, Liu LF, Kraemer FB. Biochim Biophys Acta. 2011; 1811 (1): 9-16
• Hormone-sensitive lipase-knockout mice maintain high bone density during aging. Shen WJ, Liu LF, Patel S, Kraemer FB. FASEB J. 2011; 25 (8): 2722-30