Tony Wyss-Coray

Honors and Awards

• Zenith Award, Alzheimer's Association (2005)
• Distinguished Scholar Award, The John Douglas French Alzheimer’s Foundation (2005)
• Editor, Journal of Neuroinflammation (2004)
• Medical and Scientific Advisory Council, Alzheimer's Association of Northern California & Northern Nevada (2004)

Professional Education

Postdoctoral Advisees

Eva Czirr , Takeshi Fukuhara , Yingbo He , Kurt Lucin , Jian Luo

Graduate & Fellowship Program Affiliations

• Immunology
• Neurosciences

Web Site Links

• Lab Website

Industry Relationships

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Current Research Interests

Our laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer’s disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.

Publications

• The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. J Neurosci. 2009; 29 (34): 10627-37
• Bioluminescence analysis of Smad-dependent TGF-beta signaling in live mice. Luo J, Wyss-Coray T. Methods Mol Biol. 2009: 574 193-202
• Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T. Proc Natl Acad Sci U S A. 2009; 106 (29): 12145-50
• Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. Tesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T. J Neurochem. 2009; 110 (4): 1254-62
• Blood protein signature for the early diagnosis of Alzheimer disease. Britschgi M, Wyss-Coray T. Arch Neurol. 2009; 66 (2): 161-5