Tony Wyss-Coray
Academic Appointments
- Associate Professor (Research), Neurology & Neurological Sciences
Professional Snapshot
Honors and Awards
- Zenith Award, Alzheimer's Association (2005)
- Distinguished Scholar Award, The John Douglas French Alzheimer’s Foundation (2005)
- Editor, Journal of Neuroinflammation (2004)
- Medical and Scientific Advisory Council, Alzheimer's Association of Northern California & Northern Nevada (2004)
Education & Community
Professional Education
- M.S., University of Bern, Switzerland, Microbiology (1989)
- Ph.D., University of Bern, Switzerland, Immunology (1992)
Postdoctoral Advisees
Eva Czirr, Takeshi Fukuhara, Yingbo He, Kurt Lucin, Jian Luo
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Research Interests
Our laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer’s disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.
Publications
- Blood protein signature for the early diagnosis of Alzheimer disease. "Arch Neurol" 2009 ; 2 161-5
- Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. "J Neurochem" 2009
- Live imaging of Smad2/3 signaling in mouse skin wound healing. "Wound Repair Regen" 2007 Sep-Oct ; 5 762-6
- Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance. "J Allergy Clin Immunol" 2007 ; 4 916-23
- Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. "J Immunol" 2007 ; 4 2170-9
Help