{"result":[{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Teruel","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14171&type=small&showNoImage","displayName":"Mary Frances Nunez Teruel","firstName":"Mary","href":"http://med.stanford.edu/profiles/Mary_Teruel","researchInterest":"The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and cell signaling with particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://med.stanford.edu/profiles/Mickey_Hu","researchInterest":""},{"lastName":"Palaniyandi","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9512&type=small&showNoImage","displayName":"Suresh Palaniyandi PhD","firstName":"Suresh","href":"http://med.stanford.edu/profiles/Suresh_Palaniyandi","researchInterest":"Working on drug discovery research\r\nI'm looking at pathophysiology of cardiovascular diseases and evluating potential agents for cardiac complications\r\nPKC signaling in mast cells and in heart failure\r\nALDH in diabetic cardiomyopathy"},{"lastName":"Kuo","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14091&type=small&showNoImage","displayName":"Peiwen Kuo","firstName":"Peiwen","href":"http://med.stanford.edu/profiles/Peiwen_Kuo","researchInterest":""},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=18501&type=small&showNoImage","displayName":"Wing Tak Jack Wong","firstName":"Wing Tak Jack","href":"http://med.stanford.edu/profiles/Wing Tak Jack_Wong","researchInterest":""},{"lastName":"Ruiz-Lozano","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Pediatrics - Cardiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Associate Professor (Research),Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=18359&type=small&showNoImage","displayName":"Pilar Ruiz-Lozano, Ph.D.","firstName":"Pilar","href":"http://med.stanford.edu/profiles/Pilar_Ruiz-Lozano","researchInterest":"Cardiac development and repair"},{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Cartwright","clinicalFocus":[{"focus":"Gastroenterology"},{"focus":"Inflammatory Bowel Diseases"}],"appointments":[{"appointment":"Professor,Medicine - Gastroenterology & Hepatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Gastroenterology & Hepatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4183&type=small&showNoImage","displayName":"Chris Cartwright, MD","firstName":"Christine","href":"http://med.stanford.edu/profiles/Christine_Cartwright","researchInterest":"Molecular mechanisms of intestinal cell growth control; function and regulation of the Src family of tyrosine kinases in normal cells, and their deregulation in cancer cells."},{"lastName":"Sirjani","clinicalFocus":[{"focus":"Head and Neck Neoplasms"},{"focus":"Skull Base Neoplasms"},{"focus":"Surgical Flaps"},{"focus":"Robotic Surgery"},{"focus":"Salivary Gland Neoplasms"},{"focus":"Sialoendoscopy"},{"focus":"Parotid Neoplasms"},{"focus":"Thyroid Neoplasms"},{"focus":"Parathyroidectomy"},{"focus":"Tongue"},{"focus":"Jaw"},{"focus":"Otolaryngology"},{"focus":"Orbital Neoplasms"},{"focus":"Laryngeal Neoplasms"},{"focus":"TORS"},{"focus":"Neck Dissection"},{"focus":"Carcinoma, Skin Appendage"},{"focus":"Neoplasms, Unknown Primary"},{"focus":"Melanoma"},{"focus":"Oral Cancers"},{"focus":"Lip Neoplasms"}],"appointments":[{"appointment":"Clinical Assistant Professor,Otolaryngology (Head and Neck Surgery)"}],"primaryAppointment":"Clinical Assistant Professor,Otolaryngology (Head and Neck Surgery)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=16078&type=small&showNoImage","displayName":"Davud Sirjani","firstName":"Davud","href":"http://med.stanford.edu/profiles/Davud_Sirjani","researchInterest":"Innovation of devices to improve the quality of life of patients with advanced head and neck cancers, Microvascular free flap reconstruction of large head and neck defects to restore cosmesis and function (speech, swallowing), stem cell recovery of radiation induced salivary damage, and salivary gland cancer biology"},{"lastName":"Connolly","clinicalFocus":[{"focus":"Anatomic Pathology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"}],"primaryAppointment":"Associate Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6324&type=small&showNoImage","displayName":"Andrew J. Connolly","firstName":"Andrew","href":"http://med.stanford.edu/profiles/Andrew_Connolly","researchInterest":"My research interests are vascular biology and cardiovascular pathology.  We are currently working on gene expression in endothelial cells at sites of pathology."},{"lastName":"Pfeffer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4087&type=small&showNoImage","displayName":"Suzanne Pfeffer","firstName":"Suzanne","href":"http://med.stanford.edu/profiles/Suzanne_Pfeffer","researchInterest":"The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they serve as master regulators of all receptor trafficking events.  We also study how cells acquire cholesterol from the diet and from LDL."},{"lastName":"Ashley","clinicalFocus":[{"focus":"Cardiology"},{"focus":"Inherited cardiovascular disease"},{"focus":"Heart Failure"},{"focus":"Genomic medicine"},{"focus":"Hypertrophic Cardiomyopathy"},{"focus":"Cardiomyopathy, Dilated"},{"focus":"Arrhythmogenic Right Ventricular Dysplasia"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7578&type=small&showNoImage","displayName":"Euan A. Ashley","firstName":"Euan","href":"http://med.stanford.edu/profiles/Euan_Ashley","researchInterest":"The Ashley lab is focused on the application of genomics to medicine. We develop methods for the interpretation of whole genome sequencing data to improve diagnosis of genetic disease and to personalize the practice of medicine. We also use RNA sequencing data to generate gene networks and link communities. Half of the lab is wet benches where we take advantage of cell systems, transgenic models and microsurgical models of disease to prove causality of our favorite targets."},{"lastName":"Nguyen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Stanford Cancer Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Stanford Cancer Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=24227&type=small&showNoImage","displayName":"Le Xuan Truong Nguyen","firstName":"Le Xuan Truong","href":"http://med.stanford.edu/profiles/Le Xuan Truong_Nguyen","researchInterest":""},{"lastName":"Yue","clinicalFocus":[{"focus":"Cardiovascular Disease"},{"focus":"Cardiovascular Medicine"}],"appointments":[],"imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8441&type=small&showNoImage","displayName":"Patrick Yue","firstName":"Patrick","href":"http://med.stanford.edu/profiles/Patrick_Yue","researchInterest":"My primary research focus has been the mechanisms of insulin resistance and diabetes as they pertain to the heart.  I am particularly interested in the potential involvement of the recently discovered peptide hormone apelin.  Recent studies in my laboratory group have focused on apelin's role in promoting insulin sensitivity on the systemic, tissue-specific, and cellular level.  We are currently investigating apelin-mediated signaling events in insulin-sensitive and -resistant cardiac muscle."},{"lastName":"Kendig","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Anesthesia"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4161&type=small&showNoImage","displayName":"Joan Kendig","firstName":"Joan","href":"http://med.stanford.edu/profiles/Joan_Kendig","researchInterest":"My laboratory tries to find out how pharmacologic agents used in the practice of anesthesia (general anesthetic and analgesic agents) lead to therapeutically desireable endpoints including unconsciousness, immobility and absence of pain. The old idea that general anesthetics are uniformly non-specific \"membrane stabilizers\" is giving way to a new realization that these agents exert specific actions on particular ion channels and intracellular signalling systems."},{"lastName":"Clusin","clinicalFocus":[{"focus":"Cardiovascular Disease"},{"focus":"Cardiovascular Medicine"},{"focus":"Electrocardiography"}],"appointments":[{"appointment":"Associate Professor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Associate Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4502&type=small&showNoImage","displayName":"William Clusin, MD","firstName":"William","href":"http://med.stanford.edu/profiles/William_Clusin","researchInterest":"Cardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction."},{"lastName":"Zhao","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor (Research),Neurosurgery"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor (Research),Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6432&type=small&showNoImage","displayName":"Heng Zhao","firstName":"Heng","href":"http://med.stanford.edu/profiles/Heng_Zhao","researchInterest":"My lab is focused on developing novel therapeutic methods against stroke using rodent models. We study protective effect of postconditioning, preconditioning and mild hypothermia. The rationale for studying three means of neuroprotection is that we may discover mechanisms that these treatments have in common.  Conversely, if they have differing mechanisms, we will be able to offer more than one treatment for stroke and increase a patient\u0092s chance for recovery."},{"lastName":"Sheikh","clinicalFocus":[{"focus":"Cardiothoracic Surgery and Transplantation"},{"focus":"Mechanical Circulatory Support"},{"focus":"General Surgery"}],"appointments":[{"appointment":"Clinical Instructor,Cardiothoracic Surgery - Adult Cardiac Surgery"}],"primaryAppointment":"Clinical Instructor,Cardiothoracic Surgery - Adult Cardiac Surgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=35536&type=small&showNoImage","displayName":"Ahmad Sheikh","firstName":"Ahmad","href":"http://med.stanford.edu/profiles/Ahmad_Sheikh","researchInterest":"Molecular imaging of cardiac stem cell therapy\r\nHeart failure\r\nCardiothoracic Transplantation\r\nSurgical Education"},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Dash","clinicalFocus":[{"focus":"Cardiovascular Disease"},{"focus":"Cardiovascular Medicine"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8685&type=small&showNoImage","displayName":"Rajesh Dash, MD, PhD","firstName":"Rajesh","href":"http://med.stanford.edu/profiles/Rajesh_Dash","researchInterest":"My research focuses on imaging cell signaling in the heart.  I am developing molecular imaging probes that  track to injured heart tissue, such that non-invasive imaging techniques, like cardiac MRI, can visualize these probe signals in real-time.  The translational goal of my research is to develop new ways to detect early cardiac injury before permanent damage occurs, so that preventive medical therapy can be started."},{"lastName":"Vagelos","clinicalFocus":[{"focus":"Cardiology (Heart)"},{"focus":"Cardiovascular Disease"},{"focus":"Heart and Lung Transplantation"},{"focus":"valvular heart disease"},{"focus":"Heart Failure"},{"focus":"Radiation/Chemotherapy induced cardiac disease"},{"focus":"Pericardial disease"}],"appointments":[{"appointment":"Professor - Med Center Line,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4105&type=small&showNoImage","displayName":"Randall Vagelos, MD","firstName":"Randall","href":"http://med.stanford.edu/profiles/Randall_Vagelos","researchInterest":"I. Congestive Heart Failure New Medical Therapies Prognostic Evaluation Selection for Cardiac Transplantation II. Screening for Myocardial Necrosis New ECG Monitoring Devices New Serum Markers III. Screening for CAD Patients Who Have Received Radiation Rx Diabetics Being Considered for Renal Transplantation\r\nIV. Advanced coronary and valvular disease, evaluationg candidacy for high risk interventions."},{"lastName":"Butte","clinicalFocus":[{"focus":"Allergy and Immunology"},{"focus":"Pediatric Allergy/Immun"}],"appointments":[{"appointment":"Assistant Professor,Pediatrics - Immunology and Allergy"},{"appointment":"Member,Child Health Research Institute"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Pediatrics - Immunology and Allergy","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13416&type=small&showNoImage","displayName":"Manish J. Butte, MD PhD","firstName":"Manish","href":"http://med.stanford.edu/profiles/Manish_Butte","researchInterest":"Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases."},{"lastName":"Peltz","clinicalFocus":[],"appointments":[{"appointment":"Professor,Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Anesthesia","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8527&type=small&showNoImage","displayName":"Gary Peltz","firstName":"Gary","href":"http://med.stanford.edu/profiles/Gary_Peltz","researchInterest":"The laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue."}]}