Stephen Galli

Publication Details

• Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice.

  Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H, Galli SJ. J Allergy Clin Immunol. 2007; 120 (1): 48-55

  Mast cells, IgE, and TNF, which have been implicated in human atopic asthma, contribute significantly to the allergic airway inflammation induced by ovalbumin (OVA) challenge in mice sensitized with OVA without alum. However, it is not clear to what extent mast cells represent a significant source of TNF in this mouse model.

  PubMedID: 17482668