Publications
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The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells.
Xiang H,
Noonan EJ, Wang J, Duan H, Ma L, Michie S, Boxer LM.
Leukemia.
2011;
25
(9):
1484-93
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Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells.
Duan H,
Xiang H, Ma L, Boxer LM.
Oncogene.
2008;
27
(53):
6720-8
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Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer.
Hu HM,
Kanda K, Zhang L, Boxer LM.
Leukemia.
2007;
21
(4):
747-53
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Protein/DNA arrays identify nitric oxide-regulated cis-element and trans-factor activities some of which govern neuroblastoma cell viability.
Dhakshinamoorthy S,
Sridharan SR, Li L, Ng PY, Boxer LM, Porter AG.
Nucleic Acids Res.
2007;
35
(16):
5439-51
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The immunoglobulin heavy-chain gene 3' enhancers deregulate bcl-2 promoter usage in t(14;18) lymphoma cells.
Duan H,
Heckman CA, Boxer LM.
Oncogene.
2007;
26
(18):
2635-41
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Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression.
Heckman CA,
Duan H, Garcia PB, Boxer LM.
Oncogene.
2006;
25
(6):
888-98
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Role of the cyclic AMP response element in the bcl-2 promoter in the regulation of endogenous Bcl-2 expression and apoptosis in murine B cells.
Xiang H,
Wang J, Boxer LM.
Mol Cell Biol.
2006;
26
(22):
8599-606
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Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo.
Kobayashi S,
Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, Liang Q.
FASEB J.
2006;
20
(6):
800-2
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A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.
Fine BM,
Kaspers GJ, Ho M, Loonen AH, Boxer LM.
Cancer Res.
2005;
65
(1):
291-9
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CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.
Paz-Priel I,
Cai DH, Wang D, Kowalski J, Blackford A, Liu H, Heckman CA, Gombart AF, Koeffler HP, Boxer LM, Friedman AD.
Mol Cancer Res.
2005;
3
(10):
585-96
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Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas.
Duan H,
Heckman CA, Boxer LM.
Mol Cell Biol.
2005;
25
(5):
1608-19
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Regulatory elements in the immunoglobulin heavy chain gene 3'-enhancers induce c-myc deregulation and lymphomagenesis in murine B cells.
Wang J,
Boxer LM.
J Biol Chem.
2005;
280
(13):
12766-73
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Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia.
Fine BM,
Stanulla M, Schrappe M, Ho M, Viehmann S, Harbott J, Boxer LM.
Blood.
2004;
103
(3):
1043-9
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Neurotrophin-3 and a CREB-mediated signaling pathway regulate Bcl-2 expression in oligodendrocyte progenitor cells.
Saini HS,
Gorse KM, Boxer LM, Sato-Bigbee C.
J Neurochem.
2004;
89
(4):
951-61
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Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2.
Heckman CA,
Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM.
Cancer Res.
2003;
63
(20):
6666-73
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Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells.
Jambal P,
Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S.
J Biol Chem.
2003;
278
(25):
23055-65
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Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.
Pugazhenthi S,
Nesterova A, Jambal P, Audesirk G, Kern M, Cabell L, Eves E, Rosner MR, Boxer LM, Reusch JE.
J Neurochem.
2003;
84
(5):
982-96
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Regulation of Bcl-2 expression by C/EBP in t(14;18) lymphoma cells.
Heckman CA,
Wheeler MA, Boxer LM.
Oncogene.
2003;
22
(39):
7891-9
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A Myc-associated zinc finger protein-related factor binding site is required for the deregulation of c-myc expression by the immunoglobulin heavy chain gene enhancers in Burkitt's lymphoma.
Hu HM,
Arcinas M, Boxer LM.
J Biol Chem.
2002;
277
(12):
9819-24
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Allele-specific analysis of transcription factors binding to promoter regions.
Heckman CA,
Boxer LM.
Methods.
2002;
26
(1):
19-26
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Impaired proliferation and survival of activated B cells in transgenic mice that express a dominant-negative cAMP-response element-binding protein transcription factor in B cells.
Zhang CY,
Wu YL, Boxer LM.
J Biol Chem.
2002;
277
(50):
48359-65
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NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells.
Heckman CA,
Mehew JW, Boxer LM.
Oncogene.
2002;
21
(24):
3898-908
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Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma.
Arcinas M,
Heckman CA, Mehew JW, Boxer LM.
Cancer Res.
2001;
61
(13):
5202-6
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Negative regulation of bcl-2 expression by p53 in hematopoietic cells.
Wu Y,
Mehew JW, Heckman CA, Arcinas M, Boxer LM.
Oncogene.
2001;
20
(2):
240-51
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Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl.
Sinha S,
Jancarik J, Roginskaya V, Rothermund K, Boxer LM, Corey SJ.
Exp Hematol.
2001;
29
(6):
746-55
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The critical role of the PE21 element in oncostatin M-mediated transcriptional repression of the p53 tumor suppressor gene in breast cancer cells.
Li C,
Ahlborn TE, Tokita K, Boxer LM, Noda A, Liu J.
Oncogene.
2001;
20
(57):
8193-202
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The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells.
Freeland K,
Boxer LM, Latchman DS.
Brain Res Mol Brain Res.
2001;
92
(1-2):
98-106
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Translocations involving c-myc and c-myc function.
Boxer LM,
Dang CV.
Oncogene.
2001;
20
(40):
5595-610
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A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells.
Heckman CA,
Mehew JW, Ying GG, Introna M, Golay J, Boxer LM.
J Biol Chem.
2000;
275
(9):
6499-508
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Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.
Pugazhenthi S,
Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE.
J Biol Chem.
2000;
275
(15):
10761-6
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NF-kappa B activity is required for the deregulation of c-myc expression by the immunoglobulin heavy chain enhancer.
Kanda K,
Hu HM, Zhang L, Grandchamps J, Boxer LM.
J Biol Chem.
2000;
275
(41):
32338-46
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Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma cells.
Groot M,
Boxer LM, Thiel G.
Eur J Cell Biol.
2000;
79
(12):
924-35
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A zinc-finger transcription factor induced by TGF-beta promotes apoptotic cell death in epithelial Mv1Lu cells.
Chalaux E,
López-Rovira T, Rosa JL, Pons G, Boxer LM, Bartrons R, Ventura F.
FEBS Lett.
1999;
457
(3):
478-82
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Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade.
Liu YZ,
Boxer LM, Latchman DS.
Nucleic Acids Res.
1999;
27
(10):
2086-90
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Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.
Pugazhenthi S,
Miller E, Sable C, Young P, Heidenreich KA, Boxer LM, Reusch JE.
J Biol Chem.
1999;
274
(39):
27529-35
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The expression of p53 tumor suppressor gene in breast cancer cells is down-regulated by cytokine oncostatin M.
Liu J,
Li C, Ahlborn TE, Spence MJ, Meng L, Boxer LM.
Cell Growth Differ.
1999;
10
(10):
677-83
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p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.
Budhram-Mahadeo V,
Morris PJ, Smith MD, Midgley CA, Boxer LM, Latchman DS.
J Biol Chem.
1999;
274
(21):
15237-44
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Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor.
Smith MD,
Ensor EA, Coffin RS, Boxer LM, Latchman DS.
J Biol Chem.
1998;
273
(27):
16715-22
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The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression.
Smith MD,
Dawson SJ, Boxer LM, Latchman DS.
Nucleic Acids Res.
1998;
26
(18):
4100-7
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Identification of the major positive regulators of c-myb expression in hematopoietic cells of different lineages.
Sullivan J,
Feeley B, Guerra J, Boxer LM.
J Biol Chem.
1997;
272
(3):
1943-9
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The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas.
Heckman C,
Mochon E, Arcinas M, Boxer LM.
J Biol Chem.
1997;
272
(31):
19609-14
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CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas.
Ji L,
Mochon E, Arcinas M, Boxer LM.
J Biol Chem.
1996;
271
(37):
22687-91
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Identification of an inducible regulator of c-myb expression during T-cell activation.
Phan SC,
Feeley B, Withers D, Boxer LM.
Mol Cell Biol.
1996;
16
(5):
2387-93
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Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis.
Wilson BE,
Mochon E, Boxer LM.
Mol Cell Biol.
1996;
16
(10):
5546-56
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Myb binding sites mediate negative regulation of c-myb expression in T-cell lines.
Guerra J,
Withers DA, Boxer LM.
Blood.
1995;
86
(5):
1873-80
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Pi 1 binding sites are negative regulators of bcl-2 expression in pre-B cells.
Chen HM,
Boxer LM.
Mol Cell Biol.
1995;
15
(7):
3840-7
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Repression of the c-myb gene by WT1 protein in T and B cell lines.
McCann S,
Sullivan J, Guerra J, Arcinas M, Boxer LM.
J Biol Chem.
1995;
270
(40):
23785-9
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The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma.
Ji L,
Arcinas M, Boxer LM.
J Biol Chem.
1995;
270
(22):
13392-8
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Activation of c-myc expression by c-Abl is independent of both the DNA binding function of c-Abl and the c-myc EP site.
Arcinas M,
Sizer KC, Boxer LM.
J Biol Chem.
1994;
269
(34):
21919-24
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Differential protein binding to the c-myc promoter during differentiation of hematopoietic cell lines.
Arcinas M,
Boxer LM.
Oncogene.
1994;
9
(9):
2699-706
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NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma.
Ji L,
Arcinas M, Boxer LM.
Mol Cell Biol.
1994;
14
(12):
7967-74
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The role of oncogenes in hematologic malignancies.
Boxer LM,
Annu Rev Med.
1994:
45
1-11
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