James Spudich

Publication Details

• Quantitation of the distribution and flux of myosin-II during cytokinesis.

  Robinson DN, Cavet G, Warrick HM, Spudich JA. BMC Cell Biol. 2002: 3 4

  During cytokinesis, the cell's equator contracts against the cell's global stiffness. Identifying the biochemical basis for these mechanical parameters is essential for understanding how cells divide. To achieve this goal, the distribution and flux of the cell division machinery must be quantified. Here we report the first quantitative analysis of the distribution and flux of myosin-II, an essential element of the contractile ring.

  PubMedID: 11860600