Department: Developmental Biology
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Academic Appointments Professor, Developmental Biology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Bioengineering
Professor, Genetics
Professor (By courtesy), Biology (School of Humanities and Sciences)
Research InterestOur research is focused on the genetic regulation of animal development and its relation to birth defects, cancer, and neurodegeneration. We study mechanisms and functions of Hedgehog (Hh) signaling, which controls cell fates and growth, in the context of normal development and brain cancer. We study a neurodegenerative disease, Niemann-Pick C syndrome, that affects intracellular organelle movements and sterol homeostasis.
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Academic Appointments Professor, Developmental Biology
Member, Bio-X
Research InterestA basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry.
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