Department: Developmental Biology

• Faculty (20)
• Postdocs (43)
• All

B

• 
  Barres, Ben 
  Academic Appointments

  • Professor, Neurobiology
  • Professor, Neurology & Neurological Sciences
  • Professor (By courtesy), Ophthalmology
  • Member, Bio-X
  • Professor, Developmental Biology
  Research Interest

  Our lab is interested in the neuronal-glial interactions that underlie the development and function of the mammlian central nervous system.

• 
  Beachy, Philip A
  Academic Appointments

  • Professor, Developmental Biology
  Research Interest

  Function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.

• 
  Bejerano, Gill 
  Academic Appointments

  • Assistant Professor, Developmental Biology
  • Assistant Professor, Computer Science
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Dr. Bejerano, co-discoverer of ultraconserved elements, studies the Human Genome. Through computation and experimentation we investigate the Systems Biology parts-list of many thousands genomic regions involved in gene transcription regulation during embryonic development. Major interests include (1) the origins and evolution of these regions, (2) how they encode their individual as well as combined roles, (3) their contribute to human disease, and (4) their contribute to species adaptation.

C

• 
  Clayton, David A
  Academic Appointments

  • Emeritus Faculty, Acad Council, Developmental Biology
• 
  Crabtree, Gerald 
  Academic Appointments

  • Professor, Pathology
  • Professor, Developmental Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  The role of chromatin in stem cell formation and function. Development of small molecule regulators as experimental probes and therapeutic leads. Signaling through calcineurin and NFAT in vertebrate development.

F

• 
  Fuller, Margaret 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.

K

• 
  Kim, Seung 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor (By courtesy), Medicine
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  We study the genetics of pancreatic islet cell differentiation using molecular, embryologic and genetic methods in several model systems, including mice, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. Our knowledge of genetic and cellular pathways governing islet formation has allowed us to use stem cell lines to produce islet replacements in vitro.

• 
  Kim, Stuart 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor (By courtesy), Chemical and Systems Biology
  • Professor, Genetics
  Research Interest

  1. Functional genomic approaches to study complex biological networks 2. Mechanisms of aging in worms and in humans.

• 
  Kingsley, David 
  Academic Appointments

  • Professor, Developmental Biology
  • Member, Bio-X
  Research Interest

  My laboratory uses a variety of genetic, cellular, and molecular approaches to study skeletal development in humans, mice, and fish. Many of our studies begin with naturally occuring genetic traits that alter skeletal development. By isolating the genes responsible for these traits, it has been possible to identify key pathways that control creation of skeletal tissue, repair of fractures, susceptibility to arthritis, and dramatic modifications of skeletal morphology during vertebrate evolution

M

• 
  McAdams, Harley 
  Academic Appointments

  • Professor (Research), Developmental Biology
  • Member, Bio-X
  Research Interest

  Experimental and theoretical analysis and modeling of genetic regulatory circuits, particularly bacterial regulation and with emphasis on global regulation of Caulobacter crescentus. Bioinformatic analysis of bacterial genomes, of microarray expression patterns, and cross-species genomic analysis. Techniques: gene expression microarrays, fluorescent microscopy, electron microscopy.

N

• 
  Nusse, Roeland 
  Academic Appointments

  • Professor, Developmental Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration.

P

• 
  Porzig, Ellen 
  Academic Appointments

  • Professor (Teaching), Developmental Biology
  • Member, Bio-X
  Research Interest

  Early Human Developmental Biology: From Egg to Embryo Organogenesis: Pattern formation Sex Determination in Embryogenesis

R

• 
  Rabinovitch, Marlene 
  Academic Appointments

  • Professor, Pediatrics - Cardiology
  • Professor (By courtesy), Developmental Biology
  • Member, Bio-X
  Clinical Focus

  • Cardiology (Heart), Pediatric
  • Pediatric Cardiology
  Research Interest

  Our research focuses on understanding the regulation of genes associated with cardiovascular development and disease, through the use of cultured cells and tissues and genetically modified mouse models. A variety of different aberrant pathways are being characterized, including those related to signaling through the bone morphogenetic proteins, serotonin and the S100 family of calcium binding proteins, and those defining how a microtubule associated protein regulates mRNA translation.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital

S

• 
  Scott, Matthew 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.

• 
  Shapiro, Lucille 
  Academic Appointments

  • Professor, Developmental Biology
  • Senior Fellow (By courtesy), Spogli Inst for Intrntl Studies
  • Member, Bio-X
  Research Interest

  A basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry.

• 
  Spudich, James 
  Academic Appointments

  • Professor, Biochemistry
  • Professor, Developmental Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  The general research interest of this laboratory is the molecular basis of cell motility. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement and changes in cell shape.

T

• 
  Talbot, William 
  Academic Appointments

  • Professor, Developmental Biology
  • Member, Bio-X
  Research Interest

  We use genetic and cellular approaches to investigate the molecular basis of glial development and myelination in the zebrafish. Other projects include the genetic dissection of cell fate specification in the early embryo and functional genomics in zebrafish.

V

• 
  Villeneuve, Anne 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  Research Interest

  Mechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.

W

• 
  Weissman, Irving 
  Academic Appointments

  • Professor, Pathology - Stem Cell Institute
  • Professor, Developmental Biology
  • Professor (By courtesy), Biology (School of Humanities and Sciences)
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.

• 
  Wysocka, Joanna 
  Academic Appointments

  • Assistant Professor, Chemical and Systems Biology
  • Assistant Professor, Developmental Biology
  Research Interest

  Research in our lab focuses on mechanisms of epigenetic regulation in differentiation and development. In particular, we are studying the function of histone modifying enzymes in embryonic stem cell self-renewal and in early cell fate decisions. We are interested in the role of chromatin modifications in establishment and maintenance of gene expression patterns during normal and pathological development, and in nuclear reprogramming.