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Lucy ShapiroAcademic Appointments
Appointment
Organization
Professor
Senior Fellow (By courtesy)
Spogli Inst for Intrntl Studies
Member
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Administrative Appointments
Title
Organization
Start Year
End Year
Associate Chair
Stanford University School of Medicine - Developmental Biology
2004
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Web Site Links
Research/Lab website:
My web site
Research Interests
A basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry. The developmental program by which a single cell proceeds to a fully-developed organism involves cell divisions that yield dissimilar daughter cells. The characteristics that differentiate one daughter cell from the other result from differential transcription and subcellular positioning of regulatory and structural proteins. How this is brought about remains one of the most fundamental questions of developmental biology. To approach this question, we are studying a bacterial cell, whose simple life cycle is focused on the generation of asymmetry in the predivisional cell.
We are using full genome sequence and microarray technology to identify the genetic circuitry that controls the cell cycle in a bacterial cell with 3767 genes. Dynamic protein localization, phosphorelay signaling cascades, and spatially and temporally controlled proteolysis are overlayed on the transcription network that controls cell cycle progression and cell differentiation.
We are using full genome sequence and microarray technology to identify the genetic circuitry that controls the cell cycle in a bacterial cell with 3767 genes. Dynamic protein localization, phosphorelay signaling cascades, and spatially and temporally controlled proteolysis are overlayed on the transcription network that controls cell cycle progression and cell differentiation.
Publications
- McGrath PT, Lee H, Zhang L, Iniesta AA, Hottes AK, Tan MH, Hillson NJ, Hu P, Shapiro L, McAdams HH "High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulons." Nat Biotechnol 2007; More »
- Collier J, Shapiro L "Spatial complexity and control of a bacterial cell cycle." Curr Opin Biotechnol 2007; More »
- Thanbichler M, Iniesta AA, Shapiro L "A comprehensive set of plasmids for vanillate- and xylose-inducible gene expression in Caulobacter crescentus." Nucleic Acids Res 2007; More »
- Hillson NJ, Hu P, Andersen GL, Shapiro L "Caulobacter crescentus as a whole cell uranium biosensor." Appl Environ Microbiol 2007; More »
- Laub MT, Shapiro L, McAdams HH "Systems biology of caulobacter." Annu Rev Genet 2007; 41: 429-41 More »
124 publications: view full list
