Anne Lynn S. Chang, MD

Clinical Focus

• Dermatology
• General Dermatology
• Aging of the Skin
• Skin Cancer
• basal cell carcinoma

Administrative Appointments

• Director of Adult Dermatological Clinical Trials, Stanford Dermatology (2007 - present)

Honors and Awards

• Career Development Award, Dermatology Foundation (2009)
• Fellow, American Academy of Dermatology (2007)

Professional Education

Internet Links

• Dr. Chang's Website

Current Research Interests

Our current studies focus on aging skin in human beings, skin conditions associated with aging, and skin regeneration:
1) genetics and epigenetics of human skin aging
2) novel therapies for aging skin
3) skin conditions enriched in aging skin: non-melanoma skin cancers, acne rosacea, poor wound healing
4) induced pluripotent stem cells for regenerative and therapeutic purposes

Clinical Trials

• A Study Evaluating the Efficacy and Safety of GDC-0449 in Operable Basal Cell Carcinoma (BCC) Recruiting
• A Study of GDC-0449 (Hedgehog Pathway Inhibitor) in Patients Treated With GDC-0449 in a Previous Genentech-Sponsored Phase I or II Cancer Study Recruiting
• Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors Recruiting
• A Phase II Study of Efficacy and Safety in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma (BOLT) Recruiting
• Phase II, Multi-Center, Single-Arm, Two-Cohort Trial of GDC-0449 for Advanced Basal Cell Carcinoma No longer recruiting

Publications

• A randomized double-blind, placebo-controlled pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks Chang, AS, Alora-Palli M, Lima XT, Chang TC, Cheng C, Chung CM, Amir O, Kimball AB. Journal of Drugs in Dermatology. 2012; 11 (3): 160-66
• A simple intervention to reinforce awareness of tanning bed usage and skin cancer in non-medical skin care professionals in southern California Ng A, Chang AS, Cockburn M, Peng DH. International Journal of Dermatology. 2012 TBA
• Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers Spitale RC, Cheng MY, Chun KA, Gorell ES, Munoz CA, Kern DG, Wood SM, Knaggs HE, Wulff J, Beebe KD and Chang AS. Genome Medicine. 2012; 4 (2)
• Efficacy and safety of vismodegib in advanced basal cell carcinoma Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang AS, Low JA, Mackey HM, Yauch RL, Graham RA, Reddy JC, Hauschild A. New England Journal of Medicine. 2012 TBD
• More Than Just A Coincidence: Herpes Zoster and Acne Rosacea Appearing Together as Wolf’s Isotopic Response in an Asian Female Fijalkowski N, Wysong A, Khuu P, Chang AS, International Journal of Case Reports and Images. 2012 Feb