{"result":[{"lastName":"Quertermous","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","displayName":"Thomas Quertermous, MD","firstName":"Thomas","href":"http://med.stanford.edu/profiles/dean/researcher/Thomas_Quertermous","researchInterest":"Understanding genetic basis of cardiovascular function and disease."},{"lastName":"Attardi","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3851&type=small&showNoImage","displayName":"Laura Attardi","firstName":"Laura","href":"http://med.stanford.edu/profiles/dean/researcher/Laura_Attardi","researchInterest":"Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse."},{"lastName":"Francke","clinicalFocus":[{"focus":"Clinical Genetics"},{"focus":"Neurogenetics"}],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Pediatrics"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4281&type=small&showNoImage","displayName":"Uta Francke","firstName":"Uta","href":"http://med.stanford.edu/profiles/dean/researcher/Uta_Francke","researchInterest":"Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models: Williams-Beuren syndrome, a heterozygous 1.6 megabase deletion; Rett syndrome, caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Mechanisms of genomic imprinting: Prader Willi syndrome"},{"lastName":"Feldman","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6220&type=small&showNoImage","displayName":"Marcus Feldman","firstName":"Marcus","href":"http://med.stanford.edu/profiles/dean/researcher/Marcus_Feldman","researchInterest":""},{"lastName":"Kobilka","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4300&type=small&showNoImage","displayName":"Brian Kobilka","firstName":"Brian","href":"http://med.stanford.edu/profiles/dean/researcher/Brian_Kobilka","researchInterest":"Structure, function and physiology of adrenergic receptors."},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","displayName":"Patrick O. Brown","firstName":"Patrick","href":"http://med.stanford.edu/profiles/dean/researcher/Patrick_Brown","researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer."},{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://med.stanford.edu/profiles/dean/researcher/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Bernstein","clinicalFocus":[{"focus":"Pediatric Cardiology"},{"focus":"Pediatric Heart Transplantation"},{"focus":"Pediatric Heart Failure"}],"appointments":[{"appointment":"Professor,Pediatrics - Cardiology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4174&type=small&showNoImage","displayName":"Daniel Bernstein","firstName":"Daniel","href":"http://med.stanford.edu/profiles/dean/researcher/Daniel_Bernstein","researchInterest":"We are interested in the role of the sympathetic nervous system and its cellular components (adrenergic receptors, G proteins) in regulating cardiac development and function. We utilize gene knockout models to study the role of crosstalk between adrenergic receptors and other signaling pathways (MAPK,Akt,PKC) and in the regulation of intracellular and intramitochondrial calcium. We also develop tools for examination of cardiovascular physiologic parameters in transgenic and knockout mice."},{"lastName":"Reijo-Pera","clinicalFocus":[],"appointments":[{"appointment":"Professor,Obstetrics & Gynecology - OB GYN Institutes"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Obstetrics & Gynecology - OB GYN Institutes","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8036&type=small&showNoImage","displayName":"Renee A. Reijo Pera, Ph.D.","firstName":"Renee","href":"http://med.stanford.edu/profiles/dean/researcher/Renee_Reijo-Pera","researchInterest":"The Reijo Pera Laboratory is focused on understanding key cell fates in the embryo, including the generation of pluripotent stem cells, somatic and germ cell lineages"},{"lastName":"Hsu","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Obstetrics & Gynecology"}],"primaryAppointment":"Assistant Professor,Obstetrics & Gynecology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4078&type=small&showNoImage","displayName":"Sheau Yu Teddy Hsu","firstName":"Sheau-Yu","href":"http://med.stanford.edu/profiles/dean/researcher/Sheau-Yu_Hsu","researchInterest":""},{"lastName":"Davis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","displayName":"Ronald Davis","firstName":"Ronald","href":"http://med.stanford.edu/profiles/dean/researcher/Ronald_Davis","researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion."},{"lastName":"Buckwalter","clinicalFocus":[{"focus":"Neurology"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Neurology & Neurological Sciences"},{"appointment":"Member,Neurology & Neurological Sciences"}],"primaryAppointment":"Assistant Professor - Med Center Line,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6463&type=small&showNoImage","displayName":"Marion S. Buckwalter","firstName":"Marion","href":"http://med.stanford.edu/profiles/dean/researcher/Marion_Buckwalter","researchInterest":"Our lab focuses on how inflammatory responses after brain injury affect neurological recovery. We utilize translational approaches to understand molecular mechanisms underlying functional recovery.  Molecular events are modified in mice using either transgenic models or novel small molecule compounds, and then we evaluate the effects on functional recovery as well as on cellular and molecular responses."},{"lastName":"Sidow","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4393&type=small&showNoImage","displayName":"Arend Sidow","firstName":"Arend","href":"http://med.stanford.edu/profiles/dean/researcher/Arend_Sidow","researchInterest":"We study the function and molecular evolution of proteins and noncoding functional elements in the genome.  Please refer to our web site for more information:  http://mendel.stanford.edu/SidowLab/index.html"},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://med.stanford.edu/profiles/dean/researcher/Howard_Chang","researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis."},{"lastName":"Nusse","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","displayName":"Roeland Nusse","firstName":"Roeland","href":"http://med.stanford.edu/profiles/dean/researcher/Roeland_Nusse","researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration."},{"lastName":"Parnes","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","displayName":"Jane Parnes","firstName":"Jane","href":"http://med.stanford.edu/profiles/dean/researcher/Jane_Parnes","researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease."},{"lastName":"Fuller","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4159&type=small&showNoImage","displayName":"Margaret T. Fuller","firstName":"Margaret","href":"http://med.stanford.edu/profiles/dean/researcher/Margaret_Fuller","researchInterest":"Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis."},{"lastName":"Kingsley","clinicalFocus":[],"appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4193&type=small&showNoImage","displayName":"David Kingsley","firstName":"David","href":"http://med.stanford.edu/profiles/dean/researcher/David_Kingsley","researchInterest":"My laboratory uses a variety of genetic, cellular, and molecular approaches to study skeletal development in humans, mice, and  fish. Many of our studies begin with naturally occuring genetic traits that alter skeletal development. By isolating the genes responsible for these traits, it has been possible to identify key pathways that control creation of skeletal tissue, repair of fractures, susceptibility to arthritis, and dramatic modifications of skeletal morphology during vertebrate evolution"},{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://med.stanford.edu/profiles/dean/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development."},{"lastName":"Oro","clinicalFocus":[{"focus":"Dermatology"},{"focus":"Skin Cancer "},{"focus":"Hair disorders"}],"appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4693&type=small&showNoImage","displayName":"Anthony Oro  MD/PhD","firstName":"Anthony","href":"http://med.stanford.edu/profiles/dean/researcher/Anthony_Oro","researchInterest":"Hedgehog signaling has been implicated in the induction or maintenance of up to 25% of human tumors and a variety of birth defects.  Our lab studies Sonic hedgehog (Shh) signaling in normal hair follicle development and in the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin.  We are interested in how the local stromal environment regulates hedgehog signaling and hair follicle or tumor growth and invasion."},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/dean/researcher/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Stankunas","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9759&type=small&showNoImage","displayName":"Kryn Stankunas","firstName":"Kryn","href":"http://med.stanford.edu/profiles/dean/researcher/Kryn_Stankunas","researchInterest":""},{"lastName":"Lee","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Developmental Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Developmental Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9203&type=small&showNoImage","displayName":"Jonghyeob Lee","firstName":"Jonghyeob","href":"http://med.stanford.edu/profiles/dean/researcher/Jonghyeob_Lee","researchInterest":""},{"lastName":"Khavari","clinicalFocus":[],"appointments":[{"appointment":"Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4683&type=small&showNoImage","displayName":"Paul A. Khavari, MD, PhD","firstName":"Paul","href":"http://med.stanford.edu/profiles/dean/researcher/Paul_Khavari","researchInterest":"We work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues."},{"lastName":"Weissman","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology - Stem Cell Institute"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor (By courtesy),Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology - Stem Cell Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4605&type=small&showNoImage","displayName":"Irving Weissman","firstName":"Irving","href":"http://med.stanford.edu/profiles/dean/researcher/Irving_Weissman","researchInterest":"Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis."}]}