Upinder Singh
Academic Appointments
- Assistant Professor, Medicine - Infectious Diseases
- Assistant Professor, Microbiology & Immunology
- Member, Bio-X
Contact Information
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Clinical Offices
Infectious Disease Clinic 300 Pasteur Dr A175 MC 5309 Stanford, CA 94305 Tel Work (650) 723-6961 Fax (650) 725-8418
Professional Snapshot
Clinical Focus
- Infectious Disease
- Infectious Diseases
Professional Education
| Fellowship: | University of Virginia School of Medicine, VA (1998) |
| Residency: | University of Virginia Health System, VA (1995) |
| Internship: | University of Virginia Health System, VA (1993) |
| Medical Education: | Ohio State University, OH (1992) |
| BS: | Ohio State University, Biochemistry (1987) |
Postdoctoral Advisees
Gretchen Ehrenkaufer, Victor Herrera, Richard Pearson, Hanbang Zhang
Graduate & Fellowship Program Affiliations
Community & International Work
Web Site Links
Scientific Focus
Research Interests
Dr Singh studies the molecular basis of pathogenesis of a medically important parasite, Entamoeba histolytica. The work is aimed at understanding the virulence determinants that E. histolytica utilizes in causing invasive colonic and hepatic disease. Using a combination of genetic and genomic approaches we are identifying novel mechanisms that the parasite has developed for invading the human host. Additionally, we study the epidemiological trends of of amebic infection, with the goal of identifying a parasite molecular signature that correlates with invasive potential.
Publications
- An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion. Genes Dev. 2008; (12): 1636-46
- Small RNAs with 5'-polyphosphate termini associate with a Piwi-related protein and regulate gene expression in the single-celled eukaryote Entamoeba histolytica. PLoS Pathog. 2008; (11): e1000219
- A developmentally regulated Myb domain protein regulates expression of a subset of stage-specific genes in Entamoeba histolytica. Cell Microbiol. 2009; (6): 898-910
- Recent insights into Entamoeba development: identification of transcriptional networks associated with stage conversion. Int J Parasitol. 2009; (1): 41-7
- A pseudouridine synthase homologue is critical to cellular differentiation in Toxoplasma gondii. Eukaryot Cell. 2009; (3): 398-409
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