Stanford School of Medicine
Digestive Disease Center–

Upinder Singh

Profile: http://med.stanford.edu/profiles/Upinder_Singh/
Academic Appointments
Appointment
Organization
Assistant Professor
Medicine - Infectious Diseases
Assistant Professor
Microbiology & Immunology
Graduate & Fellowship Program Affiliations
Microbiology and Immunology ; Medicine ;
 
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
BS
Ohio State University
Biochemistry
1987
MD
Ohio State University
Medicine
1992
Postdoctoral Advisees
Gretchen Ehrenkaufer, Hanbang Zhang
Web Site Links
Research/Lab website:   Singh lab website
Research Interests

Dr Singh studies the molecular basis of pathogenesis of a medically important parasite, Entamoeba histolytica. The work is aimed at understanding the virulence determinants that E. histolytica utilizes in causing invasive colonic and hepatic disease. Using a combination of genetic and genomic approaches we are identifying novel mechanisms that the parasite has developed for invading the human host. Additionally, we study the epidemiological trends of of amebic infection, with the goal of identifying a parasite molecular signature that correlates with invasive potential.

Community and International Work
  • Investigating E. histolytica genetic diversity, Bangladesh and Georgia More »
Publications
  • Macfarlane RC, Singh U "Loss of dsRNA-based gene silencing in Entamoeba histolytica: Implications for approaches to genetic analysis." Exp Parasitol 2008; More »
  • Baxt LA, Baker RP, Singh U, Urban S "An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion." Genes Dev 2008; 22: 12: 1636-46 More »
  • Ehrenkaufer GM, Haque R, Hackney JA, Eichinger DJ, Singh U "Identification of developmentally regulated genes in Entamoeba histolytica: insights into mechanisms of stage conversion in a protozoan parasite." Cell Microbiol 2007; More »
  • Ali IK, Ehrenkaufer GM, Hackney JA, Singh U "Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression." BMC Genomics 2007; 8: 7 More »
  • Hackney JA, Ehrenkaufer GM, Singh U "Identification of putative transcriptional regulatory networks in Entamoeba histolytica using Bayesian inference." Nucleic Acids Res 2007; More »
24 publications:   view full list

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