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Olivia MartinezAcademic Appointments
Appointment
Organization
Professor (Research)
Member
Member
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Research Interests
There are two major areas of focus in the laboratory. First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular focus on resistance to cell death receptor pathways of apoptosis in EBV B cell lymphomas, the characterization of the human T cell response to EBV infected B cells and effects of immunosuppressive drugs on growth and survival of EBV B cell lymphomas. The second area of study addresses tolerance induction in solid organ transplantation. In particular we are examining the generation and characterization of regulatory T cells in allogeneic responses and the role of alternate co-stimulatory molecules in alloreactivity.
Publications
- Wai LE, Fujiki M, Takeda S, Martinez OM, Krams SM "Rapamycin, but not cyclosporine or FK506, alters natural killer cell function." Transplantation 2008; 85: 1: 145-9 More »
- Stenard F, Nguyen C, Cox K, Kambham N, Umetsu DT, Krams SM, Esquivel CO, Martinez OM "Decreases in circulating CD4(+)CD25(hi)FOXP3(+) cells and increases in intragraft FOXP3(+) cells accompany allograft rejection in pediatric liver allograft recipients." Pediatr Transplant 2008; More »
- Snow AL, Martinez OM "Epstein-Barr Virus: Evasive Maneuvers in the Development of PTLD." Am J Transplant 2007; 7: 2: 271-7 More »
- Vaysberg M, Balatoni CE, Nepomuceno RR, Krams SM, Martinez OM "Rapamycin inhibits proliferation of Epstein-Barr virus-positive B-cell lymphomas through modulation of cell-cycle protein expression." Transplantation 2007; 83: 8: 1114-21 More »
- Riddle-Taylor E, Nagasaki K, Lopez J, Esquivel CO, Martinez OM, Krams SM "Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury." Transplantation 2007; 84: 6: 778-85 More »
36 publications: view full list
