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Lucy TompkinsAcademic Appointments
Appointment
Organization
Professor
Professor
|
Curriculum Vitae Doc
Honors & Awards
Title
Organization
Date(s)
Fellow
Infectious Dis Soc of America
1987
Member
Western Assoc. Physicians
1990
Member
Am. Assoc Physicians
1995
Fellow
Am.Academy Microbiology
1997
Fellow
AAAS
2001
Administrative Appointments
Title
Organization
Start Year
End Year
Medical Director, Hospital Epidemiolgy and Infection Control Dept
Stanford Hospital and Clinics
1989
-
Associate Dean for Academic Affairs
School of Medicine
2001
-
Chief, Division of Infectious Diseases and Geographic Medicine;
Associate Dean for Academic Affairs
Department of Medicine/Stanford U. Medical School
2001
-
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
MD
Dartmouth Medical School
Medicine
1973
PhD
Georgetown U School of Medicine
Microbiology
1971
Postdoctoral Advisees
Seble Kassaye
Research Interests
Molecular and cellular basis of pathogenicity of Helicobacter pylori infection and the relationship to gastric malignancy. We are studying the interaction between Helicobacter pylori, the causative agent of peptic ulcers and gastric cancer, and gastric epithelial cells. Genes encoded by a pathogenicity island in H. pylori comprise a secretory apparatus that secretes bacterial CagA protein into target gastric epithelial cells. CagA is phosphorylated on tyrosine residues by host cell kinases and is associated with signal transduction and changes in the cytoskeleton and motility. Cells that have received CagA develop an elongated phenotype and become motile. Further studies suggest that the full-length protein localizes to junctional adhesion sites and acts as an oncoprotein to stimulate the cMET receptor, leading to changes in cell polarity, motility and differentiation, changes which may be related to the development of gastric cancer. We have used an animal model of infection to study gastric lymphoma (MALT lymphoma), including the cellular response. In addition, chronically infected animals are used to address the specific cellular interactions between adipose cells and gastric epithelial cells that are necessary to provide protective immunity following immunization.
Publications
- Van Kerkhove MD, Parsonnet J, Weingart M, Tompkins LS "Investigation of mediastinitis due to coagulase-negative staphylococci after cardiothoracic surgery." Infect Control Hosp Epidemiol 2006; 27: 3: 305-7 More »
- Chiu CY, Rouskin S, Koshy A, Urisman A, Fischer K, Yagi S, Schnurr D, Eckburg PB, Tompkins LS, Blackburn BG, Merker JD, Patterson BK, Ganem D, DeRisi JL "Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult." Clin Infect Dis 2006; 43: 8: e71-6 More »
- Bagnoli F, Buti L, Tompkins L, Covacci A, Amieva MR "Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells." Proc Natl Acad Sci U S A 2005; 102: 45: 16339-44 More »
- Baron EJ, Scott JD, Tompkins LS "Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures." Clin Infect Dis 2005; 41: 11: 1677-80 More »
- Merrell DS, Thompson LJ, Kim CC, Mitchell H, Tompkins LS, Lee A, Falkow S "Growth phase-dependent response of Helicobacter pylori to iron starvation." Infect Immun 2003; 71: 11: 6510-25 More »
50 publications: view full list
