Harry B Greenberg

Administrative Appointments

• Senior Associate Dean for Research, Stanford University School of Medicine (2002 - present)

Honors and Awards

• member, ASCI (1980)
• Member, AAP (1992)
• Fellow, AAAS (2003)
• Senior Editor, J Virology (2003-)

Professional Education

Postdoctoral Advisees

Catherine Cruz,  Nitya Nair,  Dina Uzri

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Medicine
• Microbiology and Immunology
• Infectious Diseases

Internet Links

• Stanford Center for Clinical & Translation Education Research

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information

Current Research Interests

Dr. Greenberg's current interests are in pathogenic viruses that infect the GI tract, liver and respiratory tract. His primary focus is on molecular mechanisms of pathogenesis, viral determinants of protective immunity, the molecular basis of host range, virulence and tissue tropism, vaccine development, viral immunology, and epidemiology with specific emphasis on the role of enteric viruses in less developed countries. Some of the ongoing studies in the lab deal with the following questions:
(i)What rotavirus gene(s) code for host range restriction, virulence and immunity? These studies involve the use of genetic analysis and studies of humoral and cellular immunity.

(ii)What proteins and what regions of the rotavirus proteins code for neutralizing epitopes, cell fusion activity, viral receptors, protective immunity? These studies involve sequence analysis, site-specific mutagenesis, and expression of viral genes.

(iii)What host cell genes are regulated by rotavirus replication in vitro and in vivo. These studies focus on microarray analysis and cell biology.

(iv)What are the immune effector mechanisms that mediate protection from and resolution of rotavirus infection? These studies involve animal models, cell transfer studies, FACS analysis and transgenic mice.

(v)What are the mechanisms by which class I restricted CD8 T cells modulate HCV infection. These studies involve analysis of peripheral and liver infiltrating human T cells using intracellular cytokine and tetramer techniques.

(vi)What is the basis of interferon effects on HCV? This analysis focuses on in vitro and in vivo microarray studies.

(Vii)What are the determinants of immunity to influenza following live and inactivated virus vaccination?

Clinical Trials

• Blood Sample Study of viral and Immune Responses to Treatment in People with HIV or Hepatitis C Infections Recruiting
• B-cell Immunity to Influenza Active, not recruiting

Publications

• Rhesus Rotavirus trafficking during entry into MA104 cells is restricted to the early endosome compartment. Wolf M, Deal EM, Greenberg HB. J Virol. 2012
• Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. Sasaki S, Sullivan M, Narvaez CF, Holmes TH, Furman D, Zheng NY, Nishtala M, Wrammert J, Smith K, James JA, Dekker CL, Davis MM, Wilson PC, Greenberg HB, He XS. J Clin Invest. 2011; 121 (8): 3109-19
• Plasmablast-derived polyclonal antibody response after influenza vaccination. He XS, Sasaki S, Narvaez CF, Zhang C, Liu H, Woo JC, Kemble GW, Dekker CL, Davis MM, Greenberg HB. J Immunol Methods. 2011; 365 (1-2): 67-75
• Reconciliation of rotavirus temperature-sensitive mutant collections and assignment of reassortment groups D, J, and K to genome segments. Criglar J, Greenberg HB, Estes MK, Ramig RF. J Virol. 2011; 85 (10): 5048-60
• Rhesus rotavirus entry into a polarized epithelium is endocytosis dependent and involves sequential VP4 conformational changes. Wolf M, Vo PT, Greenberg HB. J Virol. 2011; 85 (6): 2492-503