Stanford School of Medicine
Digestive Disease Center–

Chris Cartwright, MD

Profile: http://med.stanford.edu/profiles/Christine_Cartwright/
Academic Appointments
Appointment
Organization
Professor
Medicine - Gastroenterology & Hepatology
Member
Cancer Center
Graduate & Fellowship Program Affiliations
Cancer Biology ; Medicine ;
 
Honors & Awards
Title
Organization
Date(s)
Member
American Society for Clinical Investigation
1995
Premier Physician Award
Crohn's & Colitis Foundation of America - Greater Bay Area Chapter
2000
Administrative Appointments
Title
Organization
Start Year
End Year
Director, Center for Inflammatory Bowel Diseases
Stanford University School of Medicine
1989
-
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
BS
Stanford University
Biology
1973
MD
University of Utah
Medicine
1978
Postdoctoral Advisees
Gayathri Swaminathan
Research Interests

Research in my laboratory focuses on molecular mechanisms of intestinal cell growth control. A primary focus is on function and regulation of the Src family of tyrosine kinases in normal cells, and their deregulation in cancer cells. Molecular, cellular and physiologic approaches are used to explore basic questions about growth regulation. Areas of active investigation include studies of Src function in cell cycle progression, proliferation, differentiation, adhesion, survival and malignant transformation; discovery of endogenous inhibitors of Src kinases; analysis of inhibitor function in cell growth control and apoptosis; and exploration of new drug therapy for colon cancer. Our recent discovery of a Src inhibitor, RACK1, which works both to inhibit growth (by suppressing Src activity at G1 and mitotic checkpoints) and to induce death of colon cells, could be exploited for development of new and more powerful and selective strategies for treatment of human colon cancer.

Publications
  • Mamidipudi V, Dhillon NK, Parman T, Miller LD, Lee KC, Cartwright CA "RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints." Oncogene 2006; More »
  • Mamidipudi V, Zhang J, Lee KC, Cartwright CA "RACK1 regulates G1/S progression by suppressing Src kinase activity." Mol Cell Biol 2004; 24: 15: 6788-98 More »
  • Miller LD, Lee KC, Mochly-Rosen D, Cartwright CA "RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling." Oncogene 2004; 23: 33: 5682-6 More »
  • Mamidipudi V, Chang BY, Harte RA, Lee KC, Cartwright CA "RACK1 inhibits the serum- and anchorage-independent growth of v-Src transformed cells." FEBS Lett 2004; 567: 2-3: 321-6 More »
  • Kambham N, Vij R, Cartwright CA, Longacre T "Cytomegalovirus infection in steroid-refractory ulcerative colitis: a case-control study." Am J Surg Pathol 2004; 28: 3: 365-73 More »
17 publications:   view full list

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