{"result":[{"lastName":"Fan","clinicalFocus":[{"focus":"Medical Oncology"},{"focus":"Oncology (Cancer)"}],"appointments":[{"appointment":"Instructor,Medicine - Oncology"}],"primaryAppointment":"Instructor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7543&type=small&showNoImage","displayName":"Alice Fan","firstName":"Alice","href":"http://med.stanford.edu/profiles/ddc/researcher/Alice_Fan","researchInterest":"Dr. Fan studies how turning off oncogenes (cancer genes) can cause tumor regression in preclinical and clinical studies. Based on preclinical findings, she has initiated a clinical trial studying atorvastatin for the treatment of patients with certain non-Hodgkin's lymphomas. In the laboratory, she also uses preclinical models of cancer to validate new nanotechnology strategies for tumor diagnosis and treatment."},{"lastName":"Shachaf","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Microbiology & Immunology - Baxter Laboratory"}],"primaryAppointment":"Instructor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7574&type=small&showNoImage","displayName":"Catherine Shachaf","firstName":"Catherine","href":"http://med.stanford.edu/profiles/ddc/researcher/Catherine_Shachaf","researchInterest":"The focus of our research is to determine the genomic and proteomic signatures of a cancer cell, and to compare them to the signatures of normal stem cells.  The goal is to identify the pathway(s) that determine the fate of a progenitor cell \u0096 to become neoplastic or to remain normal \u0096 then to prevent the neoplastic pathway decision.\r\n\r\nWe are also developing surface enhanced Raman (SERS) nanoparticles to supplement the fluorescent molecules currently available for flow cytometry."},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://med.stanford.edu/profiles/ddc/researcher/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Cleary","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"},{"appointment":"Professor,Pediatrics"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4506&type=small&showNoImage","displayName":"Michael Cleary","firstName":"Michael","href":"http://med.stanford.edu/profiles/ddc/researcher/Michael_Cleary","researchInterest":"The role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer."},{"lastName":"Clarke","clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7126&type=small&showNoImage","displayName":"Michael F. Clarke, M.D.","firstName":"Michael","href":"http://med.stanford.edu/profiles/ddc/researcher/Michael_Clarke","researchInterest":"Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine.  In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory  focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa"},{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://med.stanford.edu/profiles/ddc/researcher/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/ddc/researcher/Amato_Giaccia","researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells."},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://med.stanford.edu/profiles/ddc/researcher/Howard_Chang","researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis."},{"lastName":"Attardi","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3851&type=small&showNoImage","displayName":"Laura Attardi","firstName":"Laura","href":"http://med.stanford.edu/profiles/ddc/researcher/Laura_Attardi","researchInterest":"Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse."},{"lastName":"Arber","clinicalFocus":[{"focus":"Anatomic/Clinical Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor - Med Center Line,Pathology"}],"primaryAppointment":"Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3925&type=small&showNoImage","displayName":"Daniel A. Arber, M.D.","firstName":"Daniel","href":"http://med.stanford.edu/profiles/ddc/researcher/Daniel_Arber","researchInterest":"I study molecular genetic and immunophenotypic changes in human hematopoietic neoplasms. These include acute and chronic leukemias, lymphoma, and splenic tumors."},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","displayName":"Leonore A. Herzenberg","firstName":"Leonore","href":"http://med.stanford.edu/profiles/ddc/researcher/Leonore_Herzenberg","researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays."},{"lastName":"Sahoo","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Pathology - Stem Cell Institute"}],"primaryAppointment":"Instructor,Pathology - Stem Cell Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10888&type=small&showNoImage","displayName":"Debashis Sahoo","firstName":"Debashis","href":"http://med.stanford.edu/profiles/ddc/researcher/Debashis_Sahoo","researchInterest":""},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus (Active) Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","displayName":"Leonard Herzenberg","firstName":"Leonard","href":"http://med.stanford.edu/profiles/ddc/researcher/Leonard_Herzenberg","researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC)."},{"lastName":"Weissman","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology - Stem Cell Institute"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor (By courtesy),Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology - Stem Cell Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4605&type=small&showNoImage","displayName":"Irving Weissman","firstName":"Irving","href":"http://med.stanford.edu/profiles/ddc/researcher/Irving_Weissman","researchInterest":"Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis."},{"lastName":"Contag","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pediatrics - Neonatology"},{"appointment":"Associate Professor,Microbiology & Immunology"},{"appointment":"Associate Professor (By courtesy),Radiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Pediatrics - Neonatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4036&type=small&showNoImage","displayName":"Christopher H. Contag","firstName":"Christopher","href":"http://med.stanford.edu/profiles/ddc/researcher/Christopher_Contag","researchInterest":"We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in \"a vacuum\" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult."},{"lastName":"Pollack","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6066&type=small&showNoImage","displayName":"Jonathan Pollack","firstName":"Jonathan","href":"http://med.stanford.edu/profiles/ddc/researcher/Jonathan_Pollack","researchInterest":"Our laboratory uses genomics approaches to explore patterns of gene expression and gene copy number alteration in both human cancer cell line model systems and in tumors, with the goals of better understanding cancer, and developing novel diagnostic and therapeutic strategies."},{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://med.stanford.edu/profiles/ddc/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development."},{"lastName":"Knox","clinicalFocus":[{"focus":"Radiation Oncology"},{"focus":"Radiation Therapy"}],"appointments":[{"appointment":"Associate Professor,Radiation Oncology - Radiation Therapy"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Radiation Oncology - Radiation Therapy","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4699&type=small&showNoImage","displayName":"Susan Knox","firstName":"Susan","href":"http://med.stanford.edu/profiles/ddc/researcher/Susan_Knox","researchInterest":"Our interests in clude 1) study of the effect of radiation on regulatory cell subpopulations and co-stimulatory molecules, 2) use of radiation as an immune modulator for optimization of transplant regimens, and 3) the role of radiation in tumor vaccine strategies."},{"lastName":"Bellovin","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10046&type=small&showNoImage","displayName":"David I. Bellovin","firstName":"David","href":"http://med.stanford.edu/profiles/ddc/researcher/David_Bellovin","researchInterest":"Currently investigating the origin, development, and treatment of MYC-induced hepatocellular carcinoma using a conditional transgenic mouse model."},{"lastName":"Diehn","clinicalFocus":[],"appointments":[{"appointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy"}],"primaryAppointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9248&type=small&showNoImage","displayName":"Maximilian Diehn, M.D., Ph.D.","firstName":"Maximilian","href":"http://med.stanford.edu/profiles/ddc/researcher/Maximilian_Diehn","researchInterest":"My lab focuses on cancer stem cell biology and its implications for cancer therapy. We are interested in developing a deeper molecular understanding of cancer stem cells, including identifying pathways and genes important for proliferation and self renewal. We also study these processes in normal adult stem cells in order to identify differences that could be exploited therapeutically. The goal of our studies is the development of novel therapeutic strategies for eliminating cancer stem cells."},{"lastName":"Natkunam","clinicalFocus":[{"focus":"Hematopathology"},{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5929&type=small&showNoImage","displayName":"Yasodha Natkunam, M.D., Ph.D","firstName":"Yasodha","href":"http://med.stanford.edu/profiles/ddc/researcher/Yasodha_Natkunam","researchInterest":"My research interests focus on the identification and characterization of markers of diagnostic and prognostic importance in hematolymphoid neoplasia."},{"lastName":"Tibshirani","clinicalFocus":[],"appointments":[{"appointment":"Professor,Health Research & Policy - Biostatistics"},{"appointment":"Professor,Statistics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Health Research & Policy - Biostatistics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4688&type=small&showNoImage","displayName":"Robert Tibshirani","firstName":"Robert","href":"http://med.stanford.edu/profiles/ddc/researcher/Robert_Tibshirani","researchInterest":"My research is in applied statistics and biostatistics. I specialize in \u000bcomputer-intensive methods for regression and classification, bootstrap, cross-validation\u000band statistical inference, and signal and image analysis for medical diagnosis."},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/ddc/researcher/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Razorenova","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiation Oncology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiation Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9869&type=small&showNoImage","displayName":"Olga Razorenova","firstName":"Olga","href":"http://med.stanford.edu/profiles/ddc/researcher/Olga_Razorenova","researchInterest":""},{"lastName":"Gambhir","clinicalFocus":[{"focus":"Nuclear Medicine"},{"focus":"Radiology"},{"focus":"PET Scan"}],"appointments":[{"appointment":"Professor,Radiology - Nuclear Medicine"},{"appointment":"Professor (By courtesy),Bioengineering"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiology - Nuclear Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3971&type=small&showNoImage","displayName":"Sanjiv Sam Gambhir, MD, PhD","firstName":"Sanjiv","href":"http://med.stanford.edu/profiles/ddc/researcher/Sanjiv_Gambhir","researchInterest":"My laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the new field of molecular imaging. Methods to image gene expression in living subjects have been developed.  Newer approaches to image fundamental cellular events with optical and radiolabeled probes are under active investigation. These imaging approaches are expected to have a fundamental impact in the study of cancer biology,  as well as in molecular therapeutics including gene therapy"}]}