David A. Relman

Publications

• The increasingly compelling moral responsibilities of life scientists. Relman DA, Hastings Cent Rep. 2013 Mar-Apr; 43 (2): 34-5
• Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States. Lin A, Bik EM, Costello EK, Dethlefsen L, Haque R, Relman DA, Singh U. PLoS One. 2013; 8 (1): e53838
• Microbiology. Undernutrition--looking within for answers. Relman DA, Science. 2013; 339 (6119): 530-2
• Restoration of the gut microbial habitat as a disease therapy. Relman DA, Nat Biotechnol. 2013; 31 (1): 35-7
• Time series community genomics analysis reveals rapid shifts in bacterial species, strains, and phage during infant gut colonization. Sharon I, Morowitz MJ, Thomas BC, Costello EK, Relman DA, Banfield JF. Genome Res. 2013; 23 (1): 111-20
• Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL. Science. 2013; 339 (6126): 1448-53
• Comparisons of clustered regularly interspaced short palindromic repeats and viromes in human saliva reveal bacterial adaptations to salivary viruses. Pride DT, Salzman J, Relman DA. Environ Microbiol. 2012; 14 (9): 2564-76
• Comparisons of distance methods for combining covariates and abundances in microbiome studies. Fukuyama J, McMurdie PJ, Dethlefsen L, Relman DA, Holmes S. Pac Symp Biocomput. 2012: 213-24
• Creating a mammalian-transmissible A/H5N1 influenza virus: social contracts, prudence, and alternative perspectives. Osterholm MT, Relman DA. J Infect Dis. 2012; 205 (11): 1636-8
• Evidence of a robust resident bacteriophage population revealed through analysis of the human salivary virome. Pride DT, Salzman J, Haynes M, Rohwer F, Davis-Long C, White RA, Loomer P, Armitage GC, Relman DA. ISME J. 2012; 6 (5): 915-26
• Gut immune maturation depends on colonization with a host-specific microbiota. Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL. Cell. 2012; 149 (7): 1578-93
• Microbiology: Learning about who we are. Relman DA, Nature. 2012; 486 (7402): 194-5
• Microbiota-targeted therapies: an ecological perspective. Lemon KP, Armitage GC, Relman DA, Fischbach MA. Sci Transl Med. 2012; 4 (137): 137rv5
• Policy: Adaptations of avian flu virus are a cause for concern. Berns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB, Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA, Vidaver AK. Nature. 2012; 482 (7384): 153-4
• Public health and biosecurity. Adaptations of avian flu virus are a cause for concern. Berns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB, Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA, Vidaver AK. Science. 2012; 335 (6069): 660-1
• Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB). Pamp SJ, Harrington ED, Quake SR, Relman DA, Blainey PC. Genome Res. 2012; 22 (6): 1107-19
• Temporal dynamics of the transcriptional response to dengue virus infection in Nicaraguan children. Popper SJ, Gordon A, Liu M, Balmaseda A, Harris E, Relman DA. PLoS Negl Trop Dis. 2012; 6 (12): e1966
• The application of ecological theory toward an understanding of the human microbiome. Costello EK, Stagaman K, Dethlefsen L, Bohannan BJ, Relman DA. Science. 2012; 336 (6086): 1255-62
• The human microbiome: ecosystem resilience and health. Relman DA, Nutr Rev. 2012: 70 Suppl 1 S2-9
• Analysis of streptococcal CRISPRs from human saliva reveals substantial sequence diversity within and between subjects over time. Pride DT, Sun CL, Salzman J, Rao N, Loomer P, Armitage GC, Banfield JF, Relman DA. Genome Res. 2011; 21 (1): 126-36
• Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Dethlefsen L, Relman DA. Proc Natl Acad Sci U S A. 2011: 108 Suppl 1 4554-61
• Metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity. Willner D, Furlan M, Schmieder R, Grasis JA, Pride DT, Relman DA, Angly FE, McDole T, Mariella RP, Rohwer F, Haynes M. Proc Natl Acad Sci U S A. 2011: 108 Suppl 1 4547-53
• Microbial genomics and infectious diseases. Relman DA, N Engl J Med. 2011; 365 (4): 347-57
• Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Yilmaz P, Kottmann R, Field D, Knight R, Cole JR, Amaral-Zettler L, Gilbert JA, Karsch-Mizrachi I, Johnston A, Cochrane G, Vaughan R, Hunter C, Park J, Morrison N, Rocca-Serra P, Sterk P, Arumugam M, Bailey M, Baumgartner L, Birren BW, Blaser MJ, Bonazzi V, Booth T, Bork P, Bushman FD, Buttigieg PL, Chain PS, Charlson E, Costello EK, Huot-Creasy H, Dawyndt P, DeSantis T, Fierer N, Fuhrman JA, Gallery RE, Gevers D, Gibbs RA, San Gil I, Gonzalez A, Gordon JI, Guralnick R, Hankeln W, Highlander S, Hugenholtz P, Jansson J, Kau AL, Kelley ST, Kennedy J, Knights D, Koren O, Kuczynski J, Kyrpides N, Larsen R, Lauber CL, Legg T, Ley RE, Lozupone CA, Ludwig W, Lyons D, Maguire E, Methé BA, Meyer F, Muegge B, Nakielny S, Nelson KE, Nemergut D, Neufeld JD, Newbold LK, Oliver AE, Pace NR, Palanisamy G, Peplies J, Petrosino J, Proctor L, Pruesse E, Quast C, Raes J, Ratnasingham S, Ravel J, Relman DA, Assunta-Sansone S, Schloss PD, Schriml L, Sinha R, Smith MI, Sodergren E, Spo A, Stombaugh J, Tiedje JM, Ward DV, Weinstock GM, Wendel D, White O, Whiteley A, Wilke A, Wortman JR, Yatsunenko T, Glöckner FO. Nat Biotechnol. 2011; 29 (5): 415-20
• Modulation of the host interferon response and ISGylation pathway by B. pertussis filamentous hemagglutinin. Dieterich C, Relman DA. PLoS One. 2011; 6 (11): e27535
• Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase. Pathan N, Franklin JL, Eleftherohorinou H, Wright VJ, Hemingway CA, Waddell SJ, Griffiths M, Dennis JL, Relman DA, Harding SE, Levin M. Crit Care Med. 2011; 39 (7): 1692-711
• Strain-resolved community genomic analysis of gut microbial colonization in a premature infant. Morowitz MJ, Denef VJ, Costello EK, Thomas BC, Poroyko V, Relman DA, Banfield JF. Proc Natl Acad Sci U S A. 2011; 108 (3): 1128-33
• Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus. Rubins KH, Hensley LE, Relman DA, Brown PO. PLoS One. 2011; 6 (1): e15615
• Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression. Brickman TJ, Cummings CA, Liew SY, Relman DA, Armstrong SK. J Bacteriol. 2011; 193 (18): 4798-812
• Transforming growth factor-beta signaling pathway in patients with Kawasaki disease. Shimizu C, Jain S, Davila S, Hibberd ML, Lin KO, Molkara D, Frazer JR, Sun S, Baker AL, Newburger JW, Rowley AH, Shulman ST, Davila S, Burgner D, Breunis WB, Kuijpers TW, Wright VJ, Levin M, Eleftherohorinou H, Coin L, Popper SJ, Relman DA, Fury W, Lin C, Mellis S, Tremoulet AH, Burns JC. Circ Cardiovasc Genet. 2011; 4 (1): 16-25
• Bacterial diversity in the oral cavity of 10 healthy individuals. Bik EM, Long CD, Armitage GC, Loomer P, Emerson J, Mongodin EF, Nelson KE, Gill SR, Fraser-Liggett CM, Relman DA. ISME J. 2010; 4 (8): 962-74
• Dissecting interferon-induced transcriptional programs in human peripheral blood cells. Waddell SJ, Popper SJ, Rubins KH, Griffiths MJ, Brown PO, Levin M, Relman DA. PLoS One. 2010; 5 (3): e9753
• Genetic technologies. Synthetic "life," ethics, national security, and public discourse. Cho MK, Relman DA. Science. 2010; 329 (5987): 38-9
• Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods. DiGiulio DB, Gervasi M, Romero R, Mazaki-Tovi S, Vaisbuch E, Kusanovic JP, Seok KS, Gómez R, Mittal P, Gotsch F, Chaiworapongsa T, Oyarzún E, Kim CJ, Relman DA. J Perinat Med. 2010; 38 (5): 503-13
• Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses. DiGiulio DB, Gervasi MT, Romero R, Vaisbuch E, Mazaki-Tovi S, Kusanovic JP, Seok KS, Gómez R, Mittal P, Gotsch F, Chaiworapongsa T, Oyarzún E, Kim CJ, Relman DA. J Perinat Med. 2010; 38 (5): 495-502
• Microbial threat lists: obstacles in the quest for biosecurity? Casadevall A, Relman DA. Nat Rev Microbiol. 2010; 8 (2): 149-54
• Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. DiGiulio DB, Romero R, Kusanovic JP, Gómez R, Kim CJ, Seok KS, Gotsch F, Mazaki-Tovi S, Vaisbuch E, Sanders K, Bik EM, Chaiworapongsa T, Oyarzún E, Relman DA. Am J Reprod Immunol. 2010; 64 (1): 38-57
• SmashCell: a software framework for the analysis of single-cell amplified genome sequences. Harrington ED, Arumugam M, Raes J, Bork P, Relman DA. Bioinformatics. 2010; 26 (23): 2979-80
• The biological century: coming to terms with risk in the life sciences. Relman DA, Nat Immunol. 2010; 11 (4): 275-8
• Cross-talk in the gut. Dinalo JE, Relman DA. Genome Biol. 2009; 10 (1): 203
• Gene transcript abundance profiles distinguish Kawasaki disease from adenovirus infection. Popper SJ, Watson VE, Shimizu C, Kanegaye JT, Burns JC, Relman DA. J Infect Dis. 2009; 200 (4): 657-66
• Majority rules? Tallying the microbial census in an abscess by means of molecular methods. DiGiulio DB, Relman DA. Clin Infect Dis. 2009; 48 (9): 1179-81
• Natural-host animal models indicate functional interchangeability between the filamentous haemagglutinins of Bordetella pertussis and Bordetella bronchiseptica and reveal a role for the mature C-terminal domain, but not the RGD motif, during infection. Julio SM, Inatsuka CS, Mazar J, Dieterich C, Relman DA, Cotter PA. Mol Microbiol. 2009; 71 (6): 1574-90
• 'Til death do us part': coming to terms with symbiotic relationships. Forward. Relman DA, Nat Rev Microbiol. 2008; 6 (10): 721-4
• Comparative analysis of viral gene expression programs during poxvirus infection: a transcriptional map of the vaccinia and monkeypox genomes. Rubins KH, Hensley LE, Bell GW, Wang C, Lefkowitz EJ, Brown PO, Relman DA. PLoS One. 2008; 3 (7): e2628
• Erratum. Huse SM, Dethlefsen L, Huber JA, Mark Welch D, Relman DA, Sogin ML. PLoS Genet. 2008; 4 (11)
• Exploring microbial diversity and taxonomy using SSU rRNA hypervariable tag sequencing. Huse SM, Dethlefsen L, Huber JA, Mark Welch D, Welch DM, Relman DA, Sogin ML. PLoS Genet. 2008; 4 (11): e1000255
• Host transmission of Salmonella enterica serovar Typhimurium is controlled by virulence factors and indigenous intestinal microbiota. Lawley TD, Bouley DM, Hoy YE, Gerke C, Relman DA, Monack DM. Infect Immun. 2008; 76 (1): 403-16
• Learning to appreciate our differences. Relman DA, J Infect Dis. 2008; 198 (1): 4-5
• Linking microbial phylogeny to metabolic activity at the single-cell level by using enhanced element labeling-catalyzed reporter deposition fluorescence in situ hybridization (EL-FISH) and NanoSIMS. Behrens S, Lösekann T, Pett-Ridge J, Weber PK, Ng WO, Stevenson BS, Hutcheon ID, Relman DA, Spormann AM. Appl Environ Microbiol. 2008; 74 (10): 3143-50
• Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. DiGiulio DB, Romero R, Amogan HP, Kusanovic JP, Bik EM, Gotsch F, Kim CJ, Erez O, Edwin S, Relman DA. PLoS One. 2008; 3 (8): e3056
• Microbiology in the post-genomic era. Medini D, Serruto D, Parkhill J, Relman DA, Donati C, Moxon R, Falkow S, Rappuoli R. Nat Rev Microbiol. 2008; 6 (6): 419-30
• Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin. Abramson T, Kedem H, Relman DA. PLoS One. 2008; 3 (11): e3825
• The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. Dethlefsen L, Huse S, Sogin ML, Relman DA. PLoS Biol. 2008; 6 (11): e280
• An ecological and evolutionary perspective on human-microbe mutualism and disease. Dethlefsen L, McFall-Ngai M, Relman DA. Nature. 2007; 449 (7164): 811-8
• Building a better virus trap. Long CD, Turner-Shelef K, Relman DA. Trends Biotechnol. 2007; 25 (12): 535-8
• Development of the human infant intestinal microbiota. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. PLoS Biol. 2007; 5 (7): e177
• Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Marcy Y, Ouverney C, Bik EM, Lösekann T, Ivanova N, Martin HG, Szeto E, Platt D, Hugenholtz P, Relman DA, Quake SR. Proc Natl Acad Sci U S A. 2007; 104 (29): 11889-94
• Gene-expression patterns reveal underlying biological processes in Kawasaki disease. Popper SJ, Shimizu C, Shike H, Kanegaye JT, Newburger JW, Sundel RP, Brown PO, Burns JC, Relman DA. Genome Biol. 2007; 8 (12): R261
• Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. Simmons CP, Popper S, Dolocek C, Chau TN, Griffiths M, Dung NT, Long TH, Hoang DM, Chau NV, Thao le TT, Hien TT, Relman DA, Farrar J. J Infect Dis. 2007; 195 (8): 1097-107
• Phase variation and microevolution at homopolymeric tracts in Bordetella pertussis. Gogol EB, Cummings CA, Burns RC, Relman DA. BMC Genomics. 2007: 8 122
• The importance of individuals and scale: moving towards single cell microbiology. Dethlefsen L, Relman DA. Environ Microbiol. 2007; 9 (1): 8-10
• The role of microbes in Crohn's disease. Eckburg PB, Relman DA. Clin Infect Dis. 2007; 44 (2): 256-62
• The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Rubins KH, Hensley LE, Wahl-Jensen V, Daddario DiCaprio KM, Young HA, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW. Genome Biol. 2007; 8 (8): R174
• Assembly of the human intestinal microbiota. Dethlefsen L, Eckburg PB, Bik EM, Relman DA. Trends Ecol Evol. 2006; 21 (9): 517-23
• Bioterrorism--preparing to fight the next war. Relman DA, N Engl J Med. 2006; 354 (2): 113-5
• Characterization of a highly conserved island in the otherwise divergent Bordetella holmesii and Bordetella pertussis genomes. Diavatopoulos DA, Cummings CA, van der Heide HG, van Gent M, Liew S, Relman DA, Mooi FR. J Bacteriol. 2006; 188 (24): 8385-94
• Early days: genomics and human responses to infection. Liu M, Popper SJ, Rubins KH, Relman DA. Curr Opin Microbiol. 2006; 9 (3): 312-9
• Genomic features of Bordetella parapertussis clades with distinct host species specificity. Brinig MM, Register KB, Ackermann MR, Relman DA. Genome Biol. 2006; 7 (9): R81
• Growth phase- and nutrient limitation-associated transcript abundance regulation in Bordetella pertussis. Nakamura MM, Liew SY, Cummings CA, Brinig MM, Dieterich C, Relman DA. Infect Immun. 2006; 74 (10): 5537-48
• How bacterial communities expand functional repertoires. Versalovic J, Relman D. PLoS Biol. 2006; 4 (12): e430
• In search of biosecurity. Relman DA, Choffnes E, Lemon SM. Science. 2006; 311 (5769): 1835
• Metagenomic analysis of the human distal gut microbiome. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE. Science. 2006; 312 (5778): 1355-9
• Molecular analysis of the bacterial microbiota in the human stomach. Bik EM, Eckburg PB, Gill SR, Nelson KE, Purdom EA, Francois F, Perez-Perez G, Blaser MJ, Relman DA. Proc Natl Acad Sci U S A. 2006; 103 (3): 732-7
• Rapid quantitative profiling of complex microbial populations. Palmer C, Bik EM, Eisen MB, Eckburg PB, Sana TR, Wolber PK, Relman DA, Brown PO. Nucleic Acids Res. 2006; 34 (1): e5
• Significant gene order and expression differences in Bordetella pertussis despite limited gene content variation. Brinig MM, Cummings CA, Sanden GN, Stefanelli P, Lawrence A, Relman DA. J Bacteriol. 2006; 188 (7): 2375-82
• Species- and strain-specific control of a complex, flexible regulon by Bordetella BvgAS. Cummings CA, Bootsma HJ, Relman DA, Miller JF. J Bacteriol. 2006; 188 (5): 1775-85
• Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma. Kampmann B, Hemingway C, Stephens A, Davidson R, Goodsall A, Anderson S, Nicol M, Schölvinck E, Relman D, Waddell S, Langford P, Sheehan B, Semple L, Wilkinson KA, Wilkinson RJ, Ress S, Hibberd M, Levin M. J Clin Invest. 2005; 115 (9): 2480-8
• Bordetella pertussis, the causative agent of whooping cough, evolved from a distinct, human-associated lineage of B. bronchiseptica. Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR. PLoS Pathog. 2005; 1 (4): e45
• Diversity of the human intestinal microbial flora. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Science. 2005; 308 (5728): 1635-8
• Genomewide analysis of the host response to malaria in Kenyan children. Griffiths MJ, Shafi MJ, Popper SJ, Hemingway CA, Kortok MM, Wathen A, Rockett KA, Mott R, Levin M, Newton CR, Marsh K, Relman DA, Kwiatkowski DP. J Infect Dis. 2005; 191 (10): 1599-611
• VCAM-1 expression on CD8+ cells correlates with enhanced anti-HIV suppressing activity. Diaz LS, Foster H, Stone MR, Fujimura S, Relman DA, Levy JA. J Immunol. 2005; 174 (3): 1574-9
• Bordetella pertussis infection of primary human monocytes alters HLA-DR expression. Shumilla JA, Lacaille V, Hornell TM, Huang J, Narasimhan S, Relman DA, Mellins ED. Infect Immun. 2004; 72 (3): 1450-62
• Bordetella species are distinguished by patterns of substantial gene loss and host adaptation. Cummings CA, Brinig MM, Lepp PW, van de Pas S, Relman DA. J Bacteriol. 2004; 186 (5): 1484-92
• Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox. Jahrling PB, Hensley LE, Martinez MJ, Leduc JW, Rubins KH, Relman DA, Huggins JW. Proc Natl Acad Sci U S A. 2004; 101 (42): 15196-200
• Methanogenic Archaea and human periodontal disease. Lepp PW, Brinig MM, Ouverney CC, Palm K, Armitage GC, Relman DA. Proc Natl Acad Sci U S A. 2004; 101 (16): 6176-81
• Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Pathan N, Hemingway CA, Alizadeh AA, Stephens AC, Boldrick JC, Oragui EE, McCabe C, Welch SB, Whitney A, O'Gara P, Nadel S, Relman DA, Harding SE, Levin M. Lancet. 2004; 363 (9404): 203-9
• The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model. Rubins KH, Hensley LE, Jahrling PB, Whitney AR, Geisbert TW, Huggins JW, Owen A, Leduc JW, Brown PO, Relman DA. Proc Natl Acad Sci U S A. 2004; 101 (42): 15190-5
• Analysis of conserved non-rRNA genes of Tropheryma whipplei. Maiwald M, Lepp PW, Relman DA. Syst Appl Microbiol. 2003; 26 (1): 3-12
• Archaea and their potential role in human disease. Eckburg PB, Lepp PW, Relman DA. Infect Immun. 2003; 71 (2): 591-6
• Cultivation of Tropheryma whipplei from cerebrospinal fluid. Maiwald M, von Herbay A, Fredricks DN, Ouverney CC, Kosek JC, Relman DA. J Infect Dis. 2003; 188 (6): 801-8
• Images in clinical medicine. Progression of the lesion at the site of inoculation after smallpox vaccination. Rubins K, Relman DA. N Engl J Med. 2003; 348 (5): 414
• Individuality and variation in gene expression patterns in human blood. Relman DA, Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Brown PO.. Proc Natl Acad Sci (USA). 2003; (100): 1896-1901
• Individuality and variation in gene expression patterns in human blood. Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA, Brown PO. Proc Natl Acad Sci U S A. 2003; 100 (4): 1896-901
• Lethal invasive cestodiasis in immunosuppressed patients. Olson PD, Yoder K, Fajardo L-G LF, Marty AM, van de Pas S, Olivier C, Relman DA. J Infect Dis. 2003; 187 (12): 1962-6
• Prevalence of bacteria of division TM7 in human subgingival plaque and their association with disease. Brinig MM, Lepp PW, Ouverney CC, Armitage GC, Relman DA. Appl Environ Microbiol. 2003; 69 (3): 1687-94
• Public health. Understanding threats to scientific openness. Petro JB, Relman DA. Science. 2003; 302 (5652): 1898
• Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei. Bentley SD, Maiwald M, Murphy LD, Pallen MJ, Yeats CA, Dover LG, Norbertczak HT, Besra GS, Quail MA, Harris DE, von Herbay A, Goble A, Rutter S, Squares R, Squares S, Barrell BG, Parkhill J, Relman DA. Lancet. 2003; 361 (9358): 637-44
• Shedding light on microbial detection. Relman DA, N Engl J Med. 2003; 349 (22): 2162-3
• Single-cell enumeration of an uncultivated TM7 subgroup in the human subgingival crevice. Ouverney CC, Armitage GC, Relman DA. Appl Environ Microbiol. 2003; 69 (10): 6294-8
• Broad-range bacterial detection and the analysis of unexplained death and critical illness. Nikkari S, Lopez FA, Lepp PW, Cieslak PR, Ladd-Wilson S, Passaro D, Danila R, Relman DA. Emerg Infect Dis. 2002; 8 (2): 188-94
• Genome-wide responses of a pathogenic bacterium to its host. Relman DA, J Clin Invest. 2002; 110 (8): 1071-3
• Genomics and microbiology. Microbial forensics--"cross-examining pathogens". Cummings CA, Relman DA. Science. 2002; 296 (5575): 1976-9
• Human herpesvirus 8 and sarcoidosis. Fredricks DN, Martin TM, Edwards AO, Rosenbaum JT, Relman DA. Clin Infect Dis. 2002; 34 (4): 559-60
• Identification of Cardiobacterium hominis by broad-range bacterial polymerase chain reaction analysis in a case of culture-negative endocarditis. Nikkari S, Gotoff R, Bourbeau PP, Brown RE, Kamal NR, Relman DA. Arch Intern Med. 2002; 162 (4): 477-9
• Mining the natural world for new pathogens. Relman DA, Am J Trop Med Hyg. 2002; 67 (2): 133-4
• Molecular identification of cyanobacteria associated with stromatolites from distinct geographical locations. Neilan BA, Burns BP, Relman DA, Lowe DR. Astrobiology. 2002; 2 (3): 271-80
• New technologies, human-microbe interactions, and the search for previously unrecognized pathogens. Relman DA, J Infect Dis. 2002: 186 Suppl 2 S254-8
• Role of phosphatidylinositol 3-kinase in the binding of Bordetella pertussis to human monocytes. Ishibashi Y, Yoshimura K, Nishikawa A, Claus S, Laudanna C, Relman DA. Cell Microbiol. 2002; 4 (12): 825-33
• Smallpox research activities: U.S. interagency collaboration, 2001. LeDuc JW, Damon I, Relman DA, Huggins J, Jahrling PB. Emerg Infect Dis. 2002; 8 (7): 743-5
• Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Boldrick JC, Alizadeh AA, Diehn M, Dudoit S, Liu CL, Belcher CE, Botstein D, Staudt LM, Brown PO, Relman DA. Proc Natl Acad Sci U S A. 2002; 99 (2): 972-7
• Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998. Hajjeh RA, Relman D, Cieslak PR, Sofair AN, Passaro D, Flood J, Johnson J, Hacker JK, Shieh WJ, Hendry RM, Nikkari S, Ladd-Wilson S, Hadler J, Rainbow J, Tappero JW, Woods CW, Conn L, Reagan S, Zaki S, Perkins BA. Emerg Infect Dis. 2002; 8 (2): 145-53
• The human body as microbial observatory. Relman DA, Nat Genet. 2002; 30 (2): 131-3
• Comparing functional genomic datasets: lessons from DNA microarray analyses of host-pathogen interactions. Diehn M, Relman DA. Curr Opin Microbiol. 2001; 4 (1): 95-101
• Does blood of healthy subjects contain bacterial ribosomal DNA? Nikkari S, McLaughlin IJ, Bi W, Dodge DE, Relman DA. J Clin Microbiol. 2001; 39 (5): 1956-9
• Invasion of human respiratory epithelial cells by Bordetella pertussis: possible role for a filamentous hemagglutinin Arg-Gly-Asp sequence and alpha5beta1 integrin. Ishibashi Y, Relman DA, Nishikawa A. Microb Pathog. 2001; 30 (5): 279-88
• Localization of Tropheryma whippelii rRNA in tissues from patients with Whipple's disease. Fredricks DN, Relman DA. J Infect Dis. 2001; 183 (8): 1229-37
• Proinflammatory and proapoptotic activities associated with Bordetella pertussis filamentous hemagglutinin. Abramson T, Kedem H, Relman DA. Infect Immun. 2001; 69 (4): 2650-8
• Sequence variability in the first internal transcribed spacer region within and among Cyclospora species is consistent with polyparasitism. Olivier C, van de Pas S, Lepp PW, Yoder K, Relman DA. Int J Parasitol. 2001; 31 (13): 1475-87
• The meaning and impact of the human genome sequence for microbiology. Relman DA, Falkow S. Trends Microbiol. 2001; 9 (5): 206-8
• Tropheryma whippelii DNA is rare in the intestinal mucosa of patients without other evidence of Whipple disease. Maiwald M, von Herbay A, Persing DH, Mitchell PP, Abdelmalek MF, Thorvilson JN, Fredricks DN, Relman DA. Ann Intern Med. 2001; 134 (2): 115-9
• Whipple's disease and Tropheryma whippelii: secrets slowly revealed. Maiwald M, Relman D. Clin Infect Dis. 2001; 32 (3): 457-63
• Using DNA microarrays to study host-microbe interactions. Cummings CA, Relman DA. Emerg Infect Dis. 2000 Sep-Oct; 6 (5): 513-25
• Rhinosporidium seeberi: a human pathogen from a novel group of aquatic protistan parasites. Fredricks DN, Jolley JA, Lepp PW, Kosek JC, Relman DA. Emerg Infect Dis. 2000 May-Jun; 6 (3): 273-82
• Collaborative multidisciplinary workshop report: detection, culture, serology, and antimicrobial susceptibility testing of Chlamydia pneumoniae. Tompkins LS, Schachter J, Boman J, Chernesky MA, Dowell S, Gaydos CA, Levison ME, Maass M, Madico G, Orfila J, Ouchi K, Peeling RW, Taylor-Robinson D, Stamm WE, Wang SP, Blasi F, Relman D. J Infect Dis. 2000: 181 Suppl 3 S460-1
• How the host 'sees' pathogens: global gene expression responses to infection. Manger ID, Relman DA. Curr Opin Immunol. 2000; 12 (2): 215-8
• Molecular characterization of Bordetella bronchiseptica filamentous haemagglutinin and its secretion machinery. Jacob-Dubuisson F, Kehoe B, Willery E, Reveneau N, Locht C, Relman DA. Microbiology. 2000: 146 ( Pt 5) 1211-21
• Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii). Maiwald M, von Herbay A, Lepp PW, Relman DA. J Bacteriol. 2000; 182 (11): 3292-7
• The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. Proc Natl Acad Sci U S A. 2000; 97 (25): 13847-52
• Absence of Kaposi's sarcoma-associated herpesvirus DNA in bacillary angiomatosis-peliosis lesions. Relman DA, Fredricks DN, Yoder KE, Mirowski G, Berger T, Koehler JE. J Infect Dis. 1999; 180 (4): 1386-9
• Application of polymerase chain reaction to the diagnosis of infectious diseases. Fredricks DN, Relman DA. Clin Infect Dis. 1999; 29 (3): 475-86; quiz 487-8
• Bacterial diversity within the human subgingival crevice. Kroes I, Lepp PW, Relman DA. Proc Natl Acad Sci U S A. 1999; 96 (25): 14547-52
• Molecular approaches for identification of infectious agents in Wegener's granulomatosis and other vasculitides. Nikkari S, Relman DA. Curr Opin Rheumatol. 1999; 11 (1): 11-6
• Molecular characterization of Cyclospora-like organisms from baboons. Lopez FA, Manglicmot J, Schmidt TM, Yeh C, Smith HV, Relman DA. J Infect Dis. 1999; 179 (3): 670-6
• Paraffin removal from tissue sections for digestion and PCR analysis. Fredricks DN, Relman DA. Biotechniques. 1999; 26 (2): 198-200
• The search for unrecognized pathogens. Relman DA, Science. 1999; 284 (5418): 1308-10
• Detection and identification of previously unrecognized microbial pathogens. Relman DA, Emerg Infect Dis. 1998 Jul-Sep; 4 (3): 382-9
• Explaining the unexplained in clinical infectious diseases: looking forward. Perkins BA, Relman D. Emerg Infect Dis. 1998 Jul-Sep; 4 (3): 395-7
• Are all Bartonella henselae strains created equal? Relman DA, Clin Infect Dis. 1998; 26 (6): 1300-1
• Culture-negative endocarditis caused by Bartonella henselae. Baorto E, Payne RM, Slater LN, Lopez F, Relman DA, Min KW, St Geme JW. J Pediatr. 1998; 132 (6): 1051-4
• Cyclospora. Soave R, Herwaldt BL, Relman DA. Infect Dis Clin North Am. 1998; 12 (1): 1-12
• Diagnostic utility of the polymerase chain reaction in 2 cases of suspected Whipple disease. Taskén K, Schulz T, Elgjo K, Skullerud K, Relman D, Brubakk O. Arch Intern Med. 1998; 158 (7): 801-3
• Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization. Cotter PA, Yuk MH, Mattoo S, Akerley BJ, Boschwitz J, Relman DA, Miller JF. Infect Immun. 1998; 66 (12): 5921-9
• Improved amplification of microbial DNA from blood cultures by removal of the PCR inhibitor sodium polyanetholesulfonate. Fredricks DN, Relman DA. J Clin Microbiol. 1998; 36 (10): 2810-6
• Infectious agents and the etiology of chronic idiopathic diseases. Fredricks DN, Relman DA. Curr Clin Top Infect Dis. 1998: 18 180-200
• Molecular and cellular microbiology: new tools of the trade. Relman DA, Wright A. Curr Opin Microbiol. 1998; 1 (3): 337-339
• PCR analysis of T. whippelii DNA in a case of Whipple's disease: effect of antibiotics and correlation with histology. Petrides PE, Müller-Höcker J, Fredricks DN, Relman DA. Am J Gastroenterol. 1998; 93 (9): 1579-82
• Radiologic features of a fatal platyhelminth (tapeworm) infection in an AIDS patient. Stark P, Relman DA, Santamaria-Fries M, Fajardo LF. AJR Am J Roentgenol. 1998; 170 (1): 136-8
• The 'emergence' of Bartonella and the development of molecular discovery methods for microbial pathogens. Relman DA, Neth J Med. 1998; 52 (6): 249-55
• Bordetella bronchiseptica expresses the fimbrial structural subunit gene fimA. Boschwitz JS, van der Heide HG, Mooi FR, Relman DA. J Bacteriol. 1997; 179 (24): 7882-5
• Bordetella pertussis infection of human monocytes inhibits antigen-dependent CD4 T cell proliferation. Boschwitz JS, Batanghari JW, Kedem H, Relman DA. J Infect Dis. 1997; 176 (3): 678-86
• Cultivation of Whipple bacillus: the irony and the ecstasy. Fredricks DN, Relman DA. Lancet. 1997; 350 (9087): 1262-3
• Diagnosis and monitoring of Whipple disease by polymerase chain reaction. Ramzan NN, Loftus E, Burgart LJ, Rooney M, Batts KP, Wiesner RH, Fredricks DN, Relman DA, Persing DH. Ann Intern Med. 1997; 126 (7): 520-7
• Emerging infections and newly-recognised pathogens. Relman DA, Neth J Med. 1997; 50 (5): 216-20
• Polymerase chain reaction-based detection of Tropheryma whippelii in central nervous system Whipple's disease. Lynch T, Odel J, Fredericks DN, Louis ED, Forman S, Rotterdam H, Fahn S, Relman DA. Ann Neurol. 1997; 42 (1): 120-4
• The Whipple bacillus lives (ex vivo)! Relman DA, J Infect Dis. 1997; 176 (3): 752-4
• Lethal infection by a previously unrecognised metazoan parasite. Santamaría-Fríes M, Fajardo LF, Sogin ML, Olson PD, Relman DA. Lancet. 1996; 347 (9018): 1797-801
• Limited role for PCR-based diagnosis of Whipple's disease from peripheral blood mononuclear cells. Marth T, Fredericks D, Strober W, Relman DA. Lancet. 1996; 348 (9019): 66-7
• Molecular phylogenetic analysis of Cyclospora, the human intestinal pathogen, suggests that it is closely related to Eimeria species. Relman DA, Schmidt TM, Gajadhar A, Sogin M, Cross J, Yoder K, Sethabutr O, Echeverria P. J Infect Dis. 1996; 173 (2): 440-5
• Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Fredericks DN, Relman DA. Clin Microbiol Rev. 1996; 9 (1): 18-33
• Brief report: uveitis caused by Tropheryma whippelii (Whipple's bacillus) Rickman LS, Freeman WR, Green WR, Feldman ST, Sullivan J, Russack V, Relman DA. N Engl J Med. 1995; 332 (6): 363-6
• Has trench fever returned? Relman DA, N Engl J Med. 1995; 332 (7): 463-4
• Bacillary angiomatosis and Rochalimaea species. Relman DA, Curr Clin Top Infect Dis. 1994: 14 205-19
• Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18). Ishibashi Y, Claus S, Relman DA. J Exp Med. 1994; 180 (4): 1225-33
• Haemophilus parainfluenzae endocarditis: application of a molecular approach for identification of pathogenic bacterial species. Hamed KA, Dormitzer PR, Su CK, Relman DA. Clin Infect Dis. 1994; 19 (4): 677-83
• Phylogenetic identification of uncultured pathogens using ribosomal RNA sequences. Schmidt TM, Relman DA. Methods Enzymol. 1994: 235 205-22
• Search for highly conserved viral and bacterial nucleic acid sequences corresponding to an etiologic agent of Kawasaki disease. Rowley AH, Wolinsky SM, Relman DA, Sambol SP, Sullivan J, Terai M, Shulman ST. Pediatr Res. 1994; 36 (5): 567-71
• Isolation of Rochalimaea species. Relman DA, N Engl J Med. 1993; 328 (19): 1422-3
• The identification of uncultured microbial pathogens. Relman DA, J Infect Dis. 1993; 168 (1): 1-8
• Identification of the uncultured bacillus of Whipple's disease. Relman DA, Schmidt TM, MacDermott RP, Falkow S. N Engl J Med. 1992; 327 (5): 293-301
• Identification of uncultured microorganisms: expanding the spectrum of characterized microbial pathogens. Relman DA, Falkow S. Infect Agents Dis. 1992; 1 (5): 245-53
• Localization of Mycobacterium avium-intracellulare within a skin lesion of bacillary angiomatosis in a patient with AIDS. Sagerman PM, Relman DA, Niroomand F, Niedt GW. Diagn Mol Pathol. 1992; 1 (3): 212-6
• Phylogenetic relationships among the agent of bacillary angiomatosis, Bartonella bacilliformis, and other alpha-proteobacteria. Relman DA, Lepp PW, Sadler KN, Schmidt TM. Mol Microbiol. 1992; 6 (13): 1801-7
• The organism causing bacillary angiomatosis, peliosis hepatis, and fever and bacteremia in immunocompromised patients. Relman DA, Falkow S, LeBoit PE, Perkocha LA, Min KW, Welch DF, Slater LN. N Engl J Med. 1991; 324 (21): 1514
• Bordetella pertussis filamentous hemagglutinin: evaluation as a protective antigen and colonization factor in a mouse respiratory infection model. Kimura A, Mountzouros KT, Relman DA, Falkow S, Cowell JL. Infect Immun. 1990; 58 (1): 7-16
• Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor. Domenighini M, Relman D, Capiau C, Falkow S, Prugnola A, Scarlato V, Rappuoli R. Mol Microbiol. 1990; 4 (5): 787-800
• Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Relman D, Tuomanen E, Falkow S, Golenbock DT, Saukkonen K, Wright SD. Cell. 1990; 61 (7): 1375-82
• The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens. Relman DA, Loutit JS, Schmidt TM, Falkow S, Tompkins LS. N Engl J Med. 1990; 323 (23): 1573-80
• Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Relman DA, Domenighini M, Tuomanen E, Rappuoli R, Falkow S. Proc Natl Acad Sci U S A. 1989; 86 (8): 2637-41
• Stomatococcus mucilaginosus endocarditis in an intravenous drug abuser. Relman DA, Ruoff K, Ferraro MJ. J Infect Dis. 1987; 155 (5): 1080-2
• Mechanical instability of the oxy-form of sickle haemoglobin. Asakura T, Agarwal PL, Relman DA, McCray JA, Chance B, Schwartz E, Friedman S, Lubin B. Nature. 1973; 244 (5416): 437-8