Philip S. Tsao, PhD
Publication Details
-
Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300.
PLoS One. 2010; (12): e14301
Phenotypic alteration of vascular smooth muscle cells (SMC) in response to injury or inflammation is an essential component of vascular disease. Evidence suggests that this process is dependent on epigenetic regulatory processes. P300, a histone acetyltransferase (HAT), activates crucial muscle-specific promoters in terminal (non-SMC) myocyte differentiation, and may be essential to SMC modulation as well.
Help