Thomas Quertermous, MD
Publication Details
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FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells.
Arterioscler Thromb Vasc Biol. 2012; (4): 988-96
Vascular endothelial growth factor (VEGF) exerts proangiogenic action and induces activation of a variety of proangiogenic signaling pathways, including the Rho family small G proteins. However, regulators of the Rho family small G proteins in vascular endothelial cells (ECs) are poorly understood. Here we attempted to clarify the expression, subcellular localization, downstream effectors, and proangiogenic role of FGD5, a member of the FGD family of guanine nucleotide exchange factors.
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