{"result":[{"lastName":"Pao","clinicalFocus":[{"focus":"Nephrology"},{"focus":"Nephrolithiasis"}],"appointments":[{"appointment":"Assistant Professor,Medicine - Nephrology"}],"primaryAppointment":"Assistant Professor,Medicine - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8440&type=small&showNoImage","displayName":"Alan C. Pao","firstName":"Alan","href":"http://med.stanford.edu/profiles/cvi/researcher/Alan_Pao","researchInterest":"We are interested in the hormonal and signal transduction pathways that control epithelial ion transport. Our model system involves tight epithelia, typically found in the distal nephron of the kidney. Clinical implications of our work include a better understanding of the pathogenesis of salt-sensitive hypertension and hypertension associated with the insulin resistance syndrome."},{"lastName":"Goodman","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3813&type=small&showNoImage","displayName":"Miriam B. Goodman","firstName":"Miriam","href":"http://med.stanford.edu/profiles/cvi/researcher/Miriam_Goodman","researchInterest":"We study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction."},{"lastName":"O'Brodovich","clinicalFocus":[{"focus":"Pediatric Pulmonary"},{"focus":"Pulmonary Medicine/Cystic Fibrosis, Pediatric"}],"appointments":[{"appointment":"Professor,Pediatrics"}],"primaryAppointment":"Professor,Pediatrics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8414&type=small&showNoImage","displayName":"Hugh O'Brodovich","firstName":"Hugh","href":"http://med.stanford.edu/profiles/cvi/researcher/Hugh_O'Brodovich","researchInterest":"Clinical: \r\nPulmonary edema, acute respiratory distress syndromes (ARDS), hyaline membrane disease (HMD), bronchopulmonary dysplasia (BPD)\r\n\r\nBasic Science: \r\nLung epithelial sodium transport"},{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://med.stanford.edu/profiles/cvi/researcher/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines."},{"lastName":"Jackson","clinicalFocus":[],"appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Cancer Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4463&type=small&showNoImage","displayName":"Peter Jackson","firstName":"Peter","href":"http://med.stanford.edu/profiles/cvi/researcher/Peter_Jackson","researchInterest":"Cell cycle and cyclin control of DNA replication ."},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://med.stanford.edu/profiles/cvi/researcher/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Jamison","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Medicine - Nephrology"},{"appointment":"Emeritus Faculty, Acad Council,Medicine - Nephrology"},{"appointment":"Academic Secretary,Academic Secretary's Office"}],"primaryAppointment":"Emeritus (Active) Professor,Medicine - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4541&type=small&showNoImage","displayName":"Rex L. Jamison","firstName":"Rex","href":"http://med.stanford.edu/profiles/cvi/researcher/Rex_Jamison","researchInterest":"Patients with advanced chronic kidney disease and end stage kidney disease have high rates of cardiovascular mortality and morbidity. The purpose of the Homocysteine Study was to determine if lowering their high plasma homocysteine levels would reduce their mortality. Secondary endpoints included reductions in myocardial infarction, stroke, and amputation of a lower extremity. The results showed there was no improvement in survival or reduction in the cardiovascular events."},{"lastName":"Kambham","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Renal Pathology"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"}],"primaryAppointment":"Associate Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3829&type=small&showNoImage","displayName":"Neeraja Kambham","firstName":"Neeraja","href":"http://med.stanford.edu/profiles/cvi/researcher/Neeraja_Kambham","researchInterest":"Research interests primarily involve medical diseases of the native and transplant kidney. Other interests include liver transplantation pathology and gastrointestinal pathology."},{"lastName":"Cimprich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Chemical and Systems Biology"},{"appointment":"Associate Professor (By courtesy),Chemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4417&type=small&showNoImage","displayName":"Karlene Cimprich","firstName":"Karlene","href":"http://med.stanford.edu/profiles/cvi/researcher/Karlene_Cimprich","researchInterest":"The use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability."},{"lastName":"Grimm","clinicalFocus":[{"focus":"Pediatric Nephrology"}],"appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Nephrology"}],"primaryAppointment":"Professor - Med Center Line,Pediatrics - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7989&type=small&showNoImage","displayName":"Paul C. Grimm","firstName":"Paul","href":"http://med.stanford.edu/profiles/cvi/researcher/Paul_Grimm","researchInterest":"Computerized image analysis of kidney and liver biopsies to quantitate and diagnose subtle changes in tissue structure. \r\nRenal Fibrosis in; \r\n-Primary Kidney Disease\r\n-Transplant Kidney Disease\r\nLiver fibrosis\r\nSteatohepatitis"},{"lastName":"Hsu","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8699&type=small&showNoImage","displayName":"Jerry Hsu","firstName":"Jerry","href":"http://med.stanford.edu/profiles/cvi/researcher/Jerry_Hsu","researchInterest":""},{"lastName":"Sims","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"primaryAppointment":"Postdoctoral Research fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10021&type=small&showNoImage","displayName":"Stacy Sims","firstName":"Stacy","href":"http://med.stanford.edu/profiles/cvi/researcher/Stacy_Sims","researchInterest":""},{"lastName":"Mochly-Rosen","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4256&type=small&showNoImage","displayName":"Daria Mochly-Rosen","firstName":"Daria","href":"http://med.stanford.edu/profiles/cvi/researcher/Daria_Mochly-Rosen","researchInterest":"We are studying the mechanism of protein kinase C-mediated signal transduction in several disease models. Based on our recent data, we proposed a working hypothesis that activated PKC isozymes bind to intracellular receptor proteins located at different subcellular sites, and that these receptors differentially bind specific PKC isozymes."},{"lastName":"Scandling","clinicalFocus":[{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Nephrology"},{"focus":"Nephrology (Kidney)"}],"appointments":[{"appointment":"Professor - Med Center Line,Medicine - Nephrology"}],"primaryAppointment":"Professor - Med Center Line,Medicine - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4276&type=small&showNoImage","displayName":"John Scandling","firstName":"John","href":"http://med.stanford.edu/profiles/cvi/researcher/John_Scandling","researchInterest":"Clinical renal transplantation; acute renal failure;, cardiovascular disease in diabetic end-stage renal disease."},{"lastName":"Sarwal","clinicalFocus":[{"focus":"Nephrology (Kidney), Pediatric"},{"focus":"Pediatric Nephrology"}],"appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Nephrology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor - Med Center Line,Pediatrics - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4430&type=small&showNoImage","displayName":"Minnie Sarwal","firstName":"Minnie","href":"http://med.stanford.edu/profiles/cvi/researcher/Minnie_Sarwal","researchInterest":"Molecular and immunological basis of transplant dysfunction and acceptance. cDNA microarray analysis of transplant rejection defined a novel role for B cells in poor prognostic categories of transplant rejection. Also identified a tolerance footprint of < 50 genes that can diagnose tolerance in peripheral blood. Pioneered the first steroid free trial in pediatric kidney transplantation, (NIH-multicenter study). Runs the Bay Area Cystinosis and Stanford Pediatric Renal Transplant clinics."},{"lastName":"Eastwood","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10621&type=small&showNoImage","displayName":"Amy L Eastwood","firstName":"Amy","href":"http://med.stanford.edu/profiles/cvi/researcher/Amy_Eastwood","researchInterest":"Dr. Amy Eastwood\u0092s career has not just bloomed\u0097it has rocketed. From her takeoff in high school where her chemistry teacher inspired her to pursue a career in science, Dr. Eastwood obtained her Ph.D. at Caltech University, which in turn drew her interest to look at her research on ion channels in a more natural environment. \r\n\r\nHouston, we have found C. elegans. Dr. Eastwood came to Stanford University in late 2008 and now, with the Stanford University\u0092s Dean Fellowship and a NIH NRSA Fellows"},{"lastName":"Nachury","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8391&type=small&showNoImage","displayName":"Maxence Nachury","firstName":"Maxence","href":"http://med.stanford.edu/profiles/cvi/researcher/Maxence_Nachury","researchInterest":"We study the primary cilium, a once-obscure cellular organelle recently \"re-discovered\" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways."},{"lastName":"Sibley","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Professor,Pathology"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4113&type=small&showNoImage","displayName":"Richard Sibley","firstName":"Richard","href":"http://med.stanford.edu/profiles/cvi/researcher/Richard_Sibley","researchInterest":"Immunologic mechanism of rejection in humans and animal, models of organ transplantation; histological definition of clinical pathology studies of various renal disorders."},{"lastName":"Salvatierra","clinicalFocus":[{"focus":"Kidney Transplantation, Pediatric"},{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Urology"}],"appointments":[{"appointment":"Emeritus Faculty-Med Ctr Line,Pediatrics"}],"primaryAppointment":"Emeritus Faculty-Med Ctr Line,Pediatrics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4212&type=small&showNoImage","displayName":"Oscar Salvatierra","firstName":"Oscar","href":"http://med.stanford.edu/profiles/cvi/researcher/Oscar_Salvatierra","researchInterest":"A. Pediatric Immunosuppression with Current Emphasis on Development of Complete Steroid-Free Immunosuppression for Children\r\n\r\nB. Changes in Hemodynamics and Blood Vessel Morphology Following Transplantation of Adult-Sized Kidneys to Infants and Small Children\r\n\r\nC. Study of Immunological and Physiological Variances in Infants and Small Children following Renal Transplantation\r\n\r\nD. Use of Small, Contracted Defunctionalized Urinary Bladders Following Kidney Transplantation"},{"lastName":"Citri","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science"}],"primaryAppointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8759&type=small&showNoImage","displayName":"Amihai Citri","firstName":"Amihai","href":"http://med.stanford.edu/profiles/cvi/researcher/Amihai_Citri","researchInterest":""},{"lastName":"Roth","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus (Active) Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4175&type=small&showNoImage","displayName":"Richard Roth","firstName":"Richard","href":"http://med.stanford.edu/profiles/cvi/researcher/Richard_Roth","researchInterest":"Insulin is one of the primary regulators of rapid anabolic responses in the body. Defects in the synthesis and/or ability of cells to respond to insulin results in the condition known as diabetes mellitus. To better design methods of treatment for this disorder, we have been focusing our research on how insulin elicits its various biological responses."},{"lastName":"Holgado-Madruga","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Neurosurgery"}],"primaryAppointment":"Instructor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7072&type=small&showNoImage","displayName":"Marina Holgado-Madruga","firstName":"Maria","href":"http://med.stanford.edu/profiles/cvi/researcher/Maria_Holgado-Madruga","researchInterest":""},{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://med.stanford.edu/profiles/cvi/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function. Development of small molecule regulators as experimental probes and therapeutic leads. Signaling through calcineurin and NFAT in vertebrate development."},{"lastName":"Sommer","clinicalFocus":[{"focus":"Diagnostic Radiology"},{"focus":"Radiology"},{"focus":"abdominal imaging and uroradiology"}],"appointments":[{"appointment":"Professor,Radiology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4310&type=small&showNoImage","displayName":"F Sommer","firstName":"F","href":"http://med.stanford.edu/profiles/cvi/researcher/F_Sommer","researchInterest":"Studies include development and preliminary clinical evaluation of advanced techniques for ultrasonic imaging and tissue characterization. A number of studies are ongoing involving advanced techniques of magnetic resonance imaging and spectroscopy with application to the GU tract."},{"lastName":"Tamura","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Nephrology"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10432&type=small&showNoImage","displayName":"Manjula Tamura","firstName":"Manjula","href":"http://med.stanford.edu/profiles/cvi/researcher/Manjula_Tamura","researchInterest":"The focus of my research is the management and outcomes of chronic kidney disease in the elderly. Current studies are aimed at understanding how chronic kidney disease and dialysis affect functional outcomes in elderly patients, such as cognitive impairment and disability."}]}