{"result":[{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://med.stanford.edu/profiles/cvi/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development."},{"lastName":"Pringle","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","displayName":"John R. Pringle","firstName":"John","href":"http://med.stanford.edu/profiles/cvi/researcher/John_Pringle","researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood."},{"lastName":"Davis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","displayName":"Ronald Davis","firstName":"Ronald","href":"http://med.stanford.edu/profiles/cvi/researcher/Ronald_Davis","researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion."},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","displayName":"Patrick O. Brown","firstName":"Patrick","href":"http://med.stanford.edu/profiles/cvi/researcher/Patrick_Brown","researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer."},{"lastName":"Collins","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10605&type=small&showNoImage","displayName":"Sean Collins","firstName":"Sean","href":"http://med.stanford.edu/profiles/cvi/researcher/Sean_Collins","researchInterest":""},{"lastName":"Fraser","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15112&type=small&showNoImage","displayName":"Hunter Fraser","firstName":"Hunter","href":"http://med.stanford.edu/profiles/cvi/researcher/Hunter_Fraser","researchInterest":""},{"lastName":"Dolmetsch","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4040&type=small&showNoImage","displayName":"Ricardo Dolmetsch","firstName":"Ricardo","href":"http://med.stanford.edu/profiles/cvi/researcher/Ricardo_Dolmetsch","researchInterest":"Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders.  We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain."},{"lastName":"Lewis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4176&type=small&showNoImage","displayName":"Richard Lewis","firstName":"Richard","href":"http://med.stanford.edu/profiles/cvi/researcher/Richard_Lewis","researchInterest":"We study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function.  Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development."},{"lastName":"Graef","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","displayName":"Isabella Graef","firstName":"Isabella","href":"http://med.stanford.edu/profiles/cvi/researcher/Isabella_Graef","researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases."},{"lastName":"Straight","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","displayName":"Aaron Straight","firstName":"Aaron","href":"http://med.stanford.edu/profiles/cvi/researcher/Aaron_Straight","researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis."},{"lastName":"Kornberg","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4308&type=small&showNoImage","displayName":"Roger Kornberg","firstName":"Roger","href":"http://med.stanford.edu/profiles/cvi/researcher/Roger_Kornberg","researchInterest":"We study the regulation of transcription, the first step in gene expression. The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells"},{"lastName":"Cherry","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4249&type=small&showNoImage","displayName":"Mike Cherry","firstName":"JMichael","href":"http://med.stanford.edu/profiles/cvi/researcher/JMichael_Cherry","researchInterest":"The focus of my group is the application of bioinformatics to the collection and dissemination genetic, genomic and cellular  information. We abstracts the published results into our database, SGD. We explore the volumes of information that have been elucidated for the budding yeast S. cerevisiae.  My research is the applied use computers and databases: designing a resource to effectively provide biological information to the research community, and the development of the Gene Ontology."},{"lastName":"Tran","clinicalFocus":[],"appointments":[{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Member,Cancer Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8562&type=small&showNoImage","displayName":"Phuoc T. Tran","firstName":"Phuoc","href":"http://med.stanford.edu/profiles/cvi/researcher/Phuoc_Tran","researchInterest":""},{"lastName":"Pfeffer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4087&type=small&showNoImage","displayName":"Suzanne Pfeffer","firstName":"Suzanne","href":"http://med.stanford.edu/profiles/cvi/researcher/Suzanne_Pfeffer","researchInterest":"The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they are localized to distinct intracellular compartments in human cells, and how they serve as master regulators of all receptor trafficking events."},{"lastName":"Skotheim","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor (By courtesy),Chemical and Systems Biology"},{"appointment":" (By courtesy),Chemical and Systems Biology"},{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor (By courtesy),Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10452&type=small&showNoImage","displayName":"Jan Skotheim","firstName":"Jan","href":"http://med.stanford.edu/profiles/cvi/researcher/Jan_Skotheim","researchInterest":"A central aim of the burgeoning field of systems biology is to understand the principles governing genetic control networks. I believe finding the principles underlying genetic circuits will occur through detailed studies and then comparisons of several natural systems. Due to its extensive development as an experimental system, our favorite model, the budding yeast cell cycle, is poised to become central to this enterprise."},{"lastName":"Kaiser","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10008&type=small&showNoImage","displayName":"Stephen Kaiser","firstName":"Stephen","href":"http://med.stanford.edu/profiles/cvi/researcher/Stephen_Kaiser","researchInterest":""},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Dermatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://med.stanford.edu/profiles/cvi/researcher/Howard_Chang","researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis."},{"lastName":"Stearns","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6244&type=small&showNoImage","displayName":"Tim Stearns","firstName":"Tim","href":"http://med.stanford.edu/profiles/cvi/researcher/Tim_Stearns","researchInterest":"We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How does the cytoskeleton effect chromosome segretation with high fidelity? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?"},{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://med.stanford.edu/profiles/cvi/researcher/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://med.stanford.edu/profiles/cvi/researcher/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Berg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Biochemistry"},{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"primaryAppointment":"Emeritus (Active) Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","displayName":"Paul Berg","firstName":"Paul","href":"http://med.stanford.edu/profiles/cvi/researcher/Paul_Berg","researchInterest":"For about 10 years until 2000, my lab\u0092s research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro"},{"lastName":"Riley","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9852&type=small&showNoImage","displayName":"Brigit Erin RILEY","firstName":"Brigit","href":"http://med.stanford.edu/profiles/cvi/researcher/Brigit_Riley","researchInterest":""},{"lastName":"Stankunas","clinicalFocus":[],"appointments":[{"appointment":"Instructor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Instructor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9759&type=small&showNoImage","displayName":"Kryn Stankunas","firstName":"Kryn","href":"http://med.stanford.edu/profiles/cvi/researcher/Kryn_Stankunas","researchInterest":""},{"lastName":"Flaherty","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biochemistry"}],"primaryAppointment":"Postdoctoral Research fellow, Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10273&type=small&showNoImage","displayName":"Patrick Flaherty","firstName":"Patrick","href":"http://med.stanford.edu/profiles/cvi/researcher/Patrick_Flaherty","researchInterest":""},{"lastName":"Martchenko","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9939&type=small&showNoImage","displayName":"Mikhail Martchenko","firstName":"Mikhail","href":"http://med.stanford.edu/profiles/cvi/researcher/Mikhail_Martchenko","researchInterest":"Fungal and bacterial pathogens and their interactions with mammalian hosts."}]}