{"result":[{"lastName":"Tsien","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4189&type=small&showNoImage","displayName":"Richard Tsien","firstName":"Richard","href":"http://med.stanford.edu/profiles/cvi/researcher/Richard_Tsien","researchInterest":"We study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology."},{"lastName":"Dolmetsch","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4040&type=small&showNoImage","displayName":"Ricardo Dolmetsch","firstName":"Ricardo","href":"http://med.stanford.edu/profiles/cvi/researcher/Ricardo_Dolmetsch","researchInterest":"Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders.  We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain."},{"lastName":"Ashley","clinicalFocus":[{"focus":"Cardiology"},{"focus":"Cardiovascular genetics"},{"focus":"Hypertrophic Cardiomyopathy"},{"focus":"Heart Failure"},{"focus":"Sports Medicine"},{"focus":"Dilated Cardiomyopathy"},{"focus":"Long QT Syndrome"},{"focus":"Peripartum cardiomyopathy"},{"focus":"Arrhythmogenic Right Ventricular Dysplasia"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7578&type=small&showNoImage","displayName":"Euan A. Ashley","firstName":"Euan","href":"http://med.stanford.edu/profiles/cvi/researcher/Euan_Ashley","researchInterest":"My research interests are translational. We use high dimensional genomic analysis to identify myocardial gene expression networks then use molecular, cellular and classical physiology tools to assay the biological systems. Our interests range from fit to failing hearts."},{"lastName":"Lewis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4176&type=small&showNoImage","displayName":"Richard Lewis","firstName":"Richard","href":"http://med.stanford.edu/profiles/cvi/researcher/Richard_Lewis","researchInterest":"We study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function.  Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development."},{"lastName":"Thompson","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6245&type=small&showNoImage","displayName":"Stuart Thompson","firstName":"Stuart","href":"http://med.stanford.edu/profiles/cvi/researcher/Stuart_Thompson","researchInterest":""},{"lastName":"Hancock","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6911&type=small&showNoImage","displayName":"E William Hancock","firstName":"E","href":"http://med.stanford.edu/profiles/cvi/researcher/E_Hancock","researchInterest":""},{"lastName":"Dubin","clinicalFocus":[{"focus":"Cardiology (Heart), Pediatric"},{"focus":"Pediatric Cardiology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pediatrics - Cardiology"}],"primaryAppointment":"Associate Professor - Med Center Line,Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4477&type=small&showNoImage","displayName":"Anne Dubin","firstName":"Anne","href":"http://med.stanford.edu/profiles/cvi/researcher/Anne_Dubin","researchInterest":"Arrhythmia management in pediatric heart failure, especially resynchronization therapy in congenital heart disease,Radio frequency catheter ablation of pediatric arrhythmias,"},{"lastName":"Froelicher","clinicalFocus":[{"focus":"Cardiology (Heart)"},{"focus":"Cardiovascular Medicine"}],"appointments":[{"appointment":"Professor - Med Center Line,Medicine - Cardiovascular Medicine"},{"appointment":"Professor - Med Center Line (By courtesy),Orthopaedic Surgery"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4191&type=small&showNoImage","displayName":"Victor Froelicher, MD","firstName":"Victor","href":"http://med.stanford.edu/profiles/cvi/researcher/Victor_Froelicher","researchInterest":"Computerized ECG and clinical data management; exercise Physiology including expired gas analysis; the effect of chronic and acute exercise on the heart; digital recording of biological signals; diagnostic use of exercise testing; development of Expert Medical System software and educational tools."},{"lastName":"Mochly-Rosen","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4256&type=small&showNoImage","displayName":"Daria Mochly-Rosen","firstName":"Daria","href":"http://med.stanford.edu/profiles/cvi/researcher/Daria_Mochly-Rosen","researchInterest":"We are studying the mechanism of protein kinase C-mediated signal transduction in several disease models. Based on our recent data, we proposed a working hypothesis that activated PKC isozymes bind to intracellular receptor proteins located at different subcellular sites, and that these receptors differentially bind specific PKC isozymes."},{"lastName":"Hsia","clinicalFocus":[{"focus":"Cardiac Electrophysiology"},{"focus":"Cardiovascular Medicine"},{"focus":"Cardiovascular Disease"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6989&type=small&showNoImage","displayName":"Henry Hsia","firstName":"Henry","href":"http://med.stanford.edu/profiles/cvi/researcher/Henry_Hsia","researchInterest":""},{"lastName":"Quertermous","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","displayName":"Thomas Quertermous, MD","firstName":"Thomas","href":"http://med.stanford.edu/profiles/cvi/researcher/Thomas_Quertermous","researchInterest":"Understanding genetic basis of cardiovascular function and disease."},{"lastName":"Heidenreich","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Cardiovascular Medicine"},{"appointment":"Associate Professor - Med Center Line (By courtesy),Health Research & Policy"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4682&type=small&showNoImage","displayName":"Paul Heidenreich, MD","firstName":"Paul","href":"http://med.stanford.edu/profiles/cvi/researcher/Paul_Heidenreich","researchInterest":"My research interests include \r\n\r\n1) The cost-effectiveness of new cardiovascular technologies. \r\nExample: tests to screen asymptomatic patients for left ventricular systolic dysfunction.\r\n\r\n2) Interventions to improve the quality of care of patients with heart disease. Examples: include clinical reminders and home monitoring.\r\n\r\n3) Outcomes research using existing clinical and administrative datasets. \r\n\r\n4) Use of echocardiography to predict prognosis (e.g. diastolic dysfunction)."},{"lastName":"Tan","clinicalFocus":[{"focus":"Kidney and Pancreas Transplantation"},{"focus":"Nephrology"},{"focus":"Nephrology (Kidney)"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Medicine - Nephrology"}],"primaryAppointment":"Assistant Professor - Med Center Line,Medicine - Nephrology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3846&type=small&showNoImage","displayName":"Jane C. Tan","firstName":"Jane","href":"http://med.stanford.edu/profiles/cvi/researcher/Jane_Tan","researchInterest":"My research relates to issues pertaining to clinical kidney transplantation. We have ongoing studies on the following topics.\r\n1. Renal senescence and kidney transplant, and chronic allograft nephropathy.\r\n2. Living donor safety and response to uninephrectomy.\r\n3. Biomarkers for post-transplant monitoring."},{"lastName":"Goodman","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3813&type=small&showNoImage","displayName":"Miriam B. Goodman","firstName":"Miriam","href":"http://med.stanford.edu/profiles/cvi/researcher/Miriam_Goodman","researchInterest":"We study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels.  We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction."},{"lastName":"Hlatky","clinicalFocus":[{"focus":"Cardiology (Heart)"},{"focus":"Cardiovascular Disease"}],"appointments":[{"appointment":"Professor,Health Research & Policy - Health Services Research"},{"appointment":"Professor,Medicine"}],"primaryAppointment":"Professor,Health Research & Policy - Health Services Research","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4142&type=small&showNoImage","displayName":"Mark Hlatky, MD","firstName":"Mark","href":"http://med.stanford.edu/profiles/cvi/researcher/Mark_Hlatky","researchInterest":"My main research work is in \"outcomes research\", especially examining the field of cardiovascular medicine.  Particular areas of interest are the integration of economic and quality of life data into randomized clinical trials, evidence-based medicine, decision models, and cost-effectiveness analysis. I am also interested in the application of novel genetic, biomarker, and imaging tests to assess risk and guide clinical management of coronary artery disease."},{"lastName":"Huguenard","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4124&type=small&showNoImage","displayName":"John Huguenard","firstName":"John","href":"http://med.stanford.edu/profiles/cvi/researcher/John_Huguenard","researchInterest":"We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks."},{"lastName":"Yazawa","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"primaryAppointment":"Postdoctoral Research fellow, Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9820&type=small&showNoImage","displayName":"Masayuki Yazawa","firstName":"Masayuki","href":"http://med.stanford.edu/profiles/cvi/researcher/Masayuki_Yazawa","researchInterest":""},{"lastName":"Leung","clinicalFocus":[{"focus":"Hematology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4150&type=small&showNoImage","displayName":"Lawrence Leung","firstName":"Lawrence","href":"http://med.stanford.edu/profiles/cvi/researcher/Lawrence_Leung","researchInterest":"Our long term interest is to have a better understanding of the natural antithrombotic pathways and the pathophysiology of vascular thrombosis. We have focused on the biology of thrombin, the key enzyme in the clotting cascade.Our goal is to develop new antithrombotic agents and devise new diagnostic tests for vascular thrombotic disorders."},{"lastName":"Giacomini","clinicalFocus":[{"focus":"Cardiology (Heart)"},{"focus":"Cardiovascular Disease"}],"appointments":[{"appointment":"Professor - Med Center Line,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor - Med Center Line,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4503&type=small&showNoImage","displayName":"John Giacomini, MD","firstName":"John","href":"http://med.stanford.edu/profiles/cvi/researcher/John_Giacomini","researchInterest":"Calcium channel blockers; membrane pharmacology;, coronary physiology; antiarrhythmic drugs; cardiac hemodynamics;, cellular mechanisms of myocyte hypertrophy."},{"lastName":"Murphy","clinicalFocus":[{"focus":"Cardiology (Heart), Pediatric"},{"focus":"Congenital Heart Disease (Adult)"},{"focus":"Echocardiography"},{"focus":"Pediatric Cardiology"}],"appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Cardiology"}],"primaryAppointment":"Professor - Med Center Line,Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4632&type=small&showNoImage","displayName":"Daniel Murphy","firstName":"Daniel","href":"http://med.stanford.edu/profiles/cvi/researcher/Daniel_Murphy","researchInterest":"Dr. Murphy's major interests are in noninvasive cardiology and clinical pediatric and  adult congenital cardiac disease. These clinical interests range from imaging of complex cardiac disease in the fetus and newborn to care of the adult with congenital heart disease. He also coordinates the Marfan clinic at LPCH.  He is the director of the Adult Congenital Cardiac Clinic at Stanford University Medical Center."},{"lastName":"Stryer","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Neurobiology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Neurobiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3795&type=small&showNoImage","displayName":"Lubert Stryer","firstName":"Lubert","href":"http://med.stanford.edu/profiles/cvi/researcher/Lubert_Stryer","researchInterest":""},{"lastName":"Mullins","clinicalFocus":[{"focus":"Pathology"},{"focus":"Molecular Pathology"}],"appointments":[{"appointment":"Instructor,Pathology"}],"primaryAppointment":"Instructor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8576&type=small&showNoImage","displayName":"Franklin Mullins","firstName":"Franklin","href":"http://med.stanford.edu/profiles/cvi/researcher/Franklin_Mullins","researchInterest":""},{"lastName":"Prince","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4531&type=small&showNoImage","displayName":"David Prince","firstName":"David","href":"http://med.stanford.edu/profiles/cvi/researcher/David_Prince","researchInterest":"Experiments examine \r\n1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability\r\n2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors; \r\n3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.\r\n4. prophylaxis of postraumatic epilepsy\r\n5. Neocortical interneuronal function/modulation"},{"lastName":"Madison","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Associate Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4321&type=small&showNoImage","displayName":"Daniel V. Madison","firstName":"Vernon","href":"http://med.stanford.edu/profiles/cvi/researcher/Vernon_Madison","researchInterest":"Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling model for mechanisms underlying memory formation in the mammalian central nervous system."},{"lastName":"Bernstein","clinicalFocus":[{"focus":"Pediatric Cardiology"},{"focus":"Pediatric Heart Transplantation"},{"focus":"Pediatric Heart Failure"}],"appointments":[{"appointment":"Professor,Pediatrics - Cardiology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pediatrics - Cardiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4174&type=small&showNoImage","displayName":"Daniel Bernstein","firstName":"Daniel","href":"http://med.stanford.edu/profiles/cvi/researcher/Daniel_Bernstein","researchInterest":"We are interested in the role of the sympathetic nervous system and its cellular components (adrenergic receptors, G proteins) in regulating cardiac development and function. We utilize gene knockout models to study the role of crosstalk between adrenergic receptors and other signaling pathways (MAPK,Akt,PKC) and in the regulation of intracellular and intramitochondrial calcium. We also develop tools for examination of cardiovascular physiologic parameters in transgenic and knockout mice."}]}