Natalie L. Rasgon
Estrogen Use in Protection from Cognitive Decline
Contact Information
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Brief
We, the researchers at Stanford University, are currently conducting research to determine the effects of estrogen therapy on memory and cognition among postmenopausal women between the ages of 50 and 65, who are at risk for cognitive decline. Study participants are followed for 2 years and are asked to participate in neuropsychological testing, positron emission tomography (PET) scan, magnetic resonance imaging (MRI) and blood draws. This research will expand current knowledge about the effects of estrogen by: 1) determining whether estrogen use among postmenopausal women at risk for cognitive decline is protective of brain metabolism, 2) identifying early predictors of cognitive decline, and 3) develop guidelines for estrogen use in postmenopausal women.
Recruiting Status:
No longer recruitingStanford Recruiting Status:
No longer recruitingCondition(s):
Intervention(s):
Phase:
N/AEligibility
Ages Eligible for Study:
45 years to 65 yearsGenders Eligible for Study:
FemaleHealth of Volunteers:
People with the conditions listed in this trial can not participate as controls.Key Inclusion Criteria:
- One or more of the following risk factors for cognitive decline:
1. Personal or family history of mood disorder
2. Hypothyroidism
3. Diabetes
4. Family history of Alzheimer's Disease
- Must be between 50-65 years (yrs) of age and have been on estrogen replacement therapy (ERT) for at least 1 yr
Key Exclusion Criteria:
- Diagnosis of possible or probable Alzheimer's disease or dementia
- Cerebrovascular disease
- Uncontrolled hypertension
- History of myocardial infarction within previous yr
- Unstable heart disease
- History of significant liver disease, pulmonary disease, or current cancer
- Contraindication for MRI (metal in body, claustrophobia, etc.)
Additional Study Details
Official Title:
Estrogen Use in Protection from Cognitive DeclineAnticipated start date:
5/1/2002Lead Sponsor:
Stanford UniversityCollaborator(s):
- NIH
- NIA
Investigator(s):
Study Type:
ObservationalPurpose:
NOTNEEDEDDuration:
LongitudinalSelection:
Defined PopulationTiming:
ProspectiveTotal Number to be Enrolled:
75Total Number to be Enrolled at Stanford:
0More Information
Locations & Contacts
Stanford Locations & Contacts:
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Non-Stanford Locations:
This study is being conducted at multiple locations, including non-Stanford locations.
This listing was last updated:
8/27/2009PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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