Stanford School of Medicine
Cardiovascular Institute–

Michele Calos

Profile: http://med.stanford.edu/profiles/Michele_Calos/
Academic Appointments
Appointment
Organization
Professor
Genetics
Graduate & Fellowship Program Affiliations
Cancer Biology ; Genetics ;
 
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
B.A.
Oxford University
Zoology
-
Ph.D.
Harvard University
Biochemistry & Molecular Biology
-
Postdoc.
University of Geneva
Biologie Moleculaire
-
Web Site Links
Research/Lab website:   Personal Web site
Research Interests

Our current research is focused on development of novel vectors and strategies for gene therapy. Our primary approach is development of vectors that will integrate at specific sites in the genome. We use the phiC31 phage integrase to mediate genomic integration. We are improving the basic technology, as well as applying it to a diverse set of tissues and diseases.

We are currently delivering integrating plasmid DNA vectors using naked DNA and in vivo and ex vivo electroporation. We are working with animal models for diseases involving blood, eye, muscle, liver, and other tissues.

Publications
  • Fish MP, Groth AC, Calos MP, Nusse R "Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid." Nat Protoc 2007; 2: 10: 2325-31 More »
  • Keravala A, Groth AC, Jarrahian S, Thyagarajan B, Hoyt JJ, Kirby PJ, Calos MP "A diversity of serine phage integrases mediate site-specific recombination in mammalian cells." Mol Genet Genomics 2006; More »
  • Keravala A, Portlock JL, Nash JA, Vitrant DG, Robbins PD, Calos MP "PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints." J Gene Med 2006; More »
  • Portlock JL, Keravala A, Bertoni C, Lee S, Rando TA, Calos MP "Long-term increase in mVEGF164 in mouse hindlimb muscle mediated by phage phiC31 integrase after nonviral DNA delivery." Hum Gene Ther 2006; 17: 8: 871-6 More »
  • Calos MP, "The phiC31 integrase system for gene therapy." Curr Gene Ther 2006; 6: 6: 633-45 More »
52 publications:   view full list

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