Merritt Maduke

Honors and Awards

• Cranefield Award, Society of General Physiologists (2008)
• Scientist Development Award, American Heart Association (2004-2007)
• Faculty Scholar, Esther Ehrman Lazard (2003-2005)

Professional Education

Postdoctoral Advisees

Carl Jonas Arnold Almqvist , Michelle Dupre , Shelley Elvington

Graduate & Fellowship Program Affiliations

• Biophysics
• Molecular and Cellular Physiology
• Neurosciences

Web Site Links

• Personal Web site

Current Research Interests

CLC chloride-transport proteins are expressed ubiquitously. Defects in these proteins are responsible for human diseases of kidney and bone, for disorders of blood-pressure regulation, and for epilepsy.

Research in the Maduke lab involves a combination of electrophysiological, structural, and biochemical methods. In addition to ongoing projects, new directions include 1) using NMR to probe ion binding and conformational changes 2) designing and implementing high-throughput fluorescence-based assays to discover inhibitors and activators of the CLCs and 3) probing mechanisms of how mutations in ClC-2 lead to epilepsy.

Publications

• Review. Proton-coupled gating in chloride channels. Lísal J, Maduke M. Philos Trans R Soc Lond B Biol Sci. 2009; 364 (1514): 181-7
• Substrate-driven conformational changes in ClC-ec1 observed by fluorine NMR. Elvington SM, Liu CW, Maduke MC. EMBO J. 2009; 28 (20): 3090-102
• Thinking outside the crystal: Complementary approaches for examining transporter conformational change. Elvington SM, Maduke M. Channels (Austin). 2008; 2 (5)
• A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane. Martinez GQ, Maduke M. PLoS One. 2008; 3 (7): e2746
• Discovery of potent CLC chloride channel inhibitors. Matulef K, Howery AE, Tan L, Kobertz WR, Du Bois J, Maduke M. ACS Chem Biol. 2008; 3 (7): 419-28