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Merritt MadukeAcademic Appointments
Appointment
Organization
Assistant Professor
Member
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Honors & Awards
Title
Organization
Date(s)
Scientist Development Award
American Heart Association
2004-2007
Faculty Scholar
Esther Ehrman Lazard
2003-2005
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
UCSD
Chemistry & Biochemistry
1995
B.S.
Wheaton College
Chemistry
1989
Postdoctoral Advisees
Shelley Elvington,
Jiri Lisal,
Aaron Miller
Web Site Links
Research/Lab website:
Personal Web site
Research Interests
CLC chloride-transport proteins are expressed ubiquitously. Defects in these proteins are responsible for human diseases of kidney and bone, for disorders of blood-pressure regulation, and for epilepsy.
Research in the Maduke lab involves a combination of electrophysiological, structural, and biochemical methods. In addition to ongoing projects, new directions include 1) using NMR to probe ion binding and conformational changes 2) designing and implementing high-throughput fluorescence-based assays to discover inhibitors and activators of the CLCs and 3) probing mechanisms of how mutations in ClC-2 lead to epilepsy.
Research in the Maduke lab involves a combination of electrophysiological, structural, and biochemical methods. In addition to ongoing projects, new directions include 1) using NMR to probe ion binding and conformational changes 2) designing and implementing high-throughput fluorescence-based assays to discover inhibitors and activators of the CLCs and 3) probing mechanisms of how mutations in ClC-2 lead to epilepsy.
Publications
- Matulef K, Maduke M "The CLC 'chloride channel' family: revelations from prokaryotes (Review)." Mol Membr Biol 2007 Sep-Oct; 24: 5: 342-50 More »
- Engh AM, Faraldo-Gómez JD, Maduke M "The Role of a Conserved Lysine in Chloride- and Voltage-dependent ClC-0 Fast Gating." J Gen Physiol 2007; More »
- Engh AM, Faraldo-Gómez JD, Maduke M "The Mechanism of Fast-Gate Opening in ClC-0." J Gen Physiol 2007; More »
- Engh AM, Maduke M "Cysteine Accessibility in ClC-0 Supports Conservation of the ClC Intracellular Vestibule." J Gen Physiol 2005; More »
- Matulef K, Maduke M "Side-dependent inhibition of a prokaryotic ClC by DIDS." Biophys J 2005; More »
12 publications: view full list
