Stanford School of Medicine
Cardiovascular Institute–

Fredric Kraemer

Email:
Profile: http://med.stanford.edu/profiles/Fredric_Kraemer/
Academic Appointments
Appointment
Organization
Professor
Medicine - Endocrinology/Gerontology/Metab
Member
Bio-X
Graduate & Fellowship Program Affiliations
Medicine ;
 
Honors & Awards
Title
Organization
Date(s)
Special Emphasis Research Career Award
NIH
1982-1987
Mellon Foundation Fellow
Stanford University
1983-1984
Hume Faculty Scholar
Stanford University
1984-1988
SmithKline Beecham Junior Faculty Award In Diabetes
SmithKline Beecham
1998
Stanford University Professorship in Endocrinology
Stanford University
2002
Administrative Appointments
Title
Organization
Start Year
End Year
Associate Chief of Staff for Research and Development
VA Palo Alto Health Care System
2002
2007
Chief, Division of Endocrinology, Gerontology and Metabolism
Stanford University
2002
-
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
BA
Emory University
Chemistry
1970
MD
New York University
Medicine
1974
Postdoctoral Advisees
Aiqin Cao, Li-Fen Liu, Minhao Wu, Weibin Xu, Syed Zaidi, Haiyan Zhang, Zhonghua Zhang
Research Interests

Our research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology. Current research projects focus on the regulation of hormone sensitive lipase (HSL). HSL is an intracellular enzyme responsible for the cytosolic hydrolysis of intracellular triglyceride and cholesteryl esters. Thus, it has an important role in fat mobilization, but also in cholesterol metabolism. We are examining all aspects of the biology of HSL, including its mechanisms of action and its structure-function relationships in regard to adipose cell function and steroid hormone synthesis.

Publications
  • Chen W, Wang S, Ma Y, Zhou Y, Liu H, Strnad P, Kraemer FB, Krauss RM, Liu J "Analysis of polymorphisms in the 3' untranslated region of the LDL receptor gene and their effect on plasma cholesterol levels and drug response." Int J Mol Med 2008; 21: 3: 345-53 More »
  • Chen TL, Shen WJ, Qiu XW, Li T, Hoffman AR, Kraemer FB "Generation of novel adipocyte monolayer cultures from embryonic stem cells." Stem Cells Dev 2007; 16: 3: 371-80 More »
  • Miyoshi H, Perfield JW, Souza SC, Shen WJ, Zhang HH, Stancheva ZS, Kraemer FB, Obin MS, Greenberg AS "Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes." J Biol Chem 2007; 282: 2: 996-1002 More »
  • Shen WJ, Patel S, Yu Z, Jue D, Kraemer FB "Effects of rosiglitazone and high fat diet on lipase/esterase expression in adipose tissue." Biochim Biophys Acta 2007; 1771: 2: 177-84 More »
  • Zhou Y, Abidi P, Kim A, Chen W, Huang TT, Kraemer FB, Liu J "Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation." Arterioscler Thromb Vasc Biol 2007; 27: 10: 2198-205 More »
113 publications:   view full list

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