Yvonne Maldonado

Clinical Focus

• Infectious Diseases, Pediatric
• Pediatric Infectious Disease

Administrative Appointments

• Medical Director, Infection Control, LPCH (2006 - present)

Professional Education

Postdoctoral Advisees

Marisa Holubar,  Candice McNeil

Graduate & Fellowship Program Affiliations

• Epidemiology
• Infectious Diseases
• Pediatrics

Current Research Interests

The research I have conducted has been focused on epidemiologic aspects of viral vaccine development and prevention of perinatal HIV transmission. A major project has been to identify the molecular epidemiology of factors affecting the immunogenicity of oral polio vaccine (OPV) among children living in developing areas of the world, where OPV immunogenicity is poor. We have identified several factors which affect the poor immunogenicity of OPV and will conduct clinical studies to attempt to improve immunogenicity. We are now working on ways to understand the transmission and circulation of polio vaccine derived viruses, which may cause polio, and how to use this information in global eradication of polio. I also work on perinatal HIV infection, including strategies to prevent breastfeeding transmission in developing settings as well as understanding how to maximize prevention strategies among pregnant women in developed countries.

A second recent project has been to define the ontogeny of the immune response to measles vaccine among young infants. The purpose is to identify specific humoral and cell-mediated immune responses to measles vaccine which affect vaccine immunogenicity and induce the immunosuppressive effects associated with measles vaccination.

A final project I have conducted since 1989 involves a long term natural history study of infants with perinatal HIV exposure and infection. This computer-based study involves following all HIV-exposed and infected infants living in the Northern California and defining factors associated with progression of HIV-related disease.

Clinical Trials

• Effect of Pre-operative Prophylaxis with Vancomycin on Rate of Cefazolin Non-susceptible Gram Positive Surgical Site Infections in Cardiovascular Surgery Patients Choose one

Publications

• Hematologic and immunologic parameters in zimbabwean infants: a case for using local reference intervals to monitor toxicities in clinical trials. Troy SB, Rowhani-Rahbar A, Dyner L, Musingwini G, Shetty AK, Woelk G, Stranix-Chibanda L, Nathoo K, Maldonado YA. J Trop Pediatr. 2012; 58 (1): 59-62
• Intradermal fractional dose inactivated polio vaccine: a review of the literature. Nelson KS, Janssen JM, Troy SB, Maldonado Y. Vaccine. 2012; 30 (2): 121-5
• Timing of antiretroviral therapy initiation and its impact on disease progression in perinatal human immunodeficiency virus-1 infection. Sturt AS, Halpern MS, Sullivan B, Maldonado YA. Pediatr Infect Dis J. 2012; 31 (1): 53-60
• Barriers to care and current medical and social needs of HIV-positive patients in Albania. Morrison SD, Banushi VH, Sarnquist C, Gashi VH, Osterberg L, Maldonado Y, Harxhi A. Cent Eur J Public Health. 2011; 19 (2): 91-7
• Epidemiologic trends in penile anomalies and hypospadias in the state of California, 1985-2006. Elliott CS, Halpern MS, Paik J, Maldonado Y, Shortliffe LD. J Pediatr Urol. 2011; 7 (3): 294-8