Irene Wapnir

Clinical Focus

• Cancer> Breast Cancer
• Cancer> Breast Cancer> Breast Cancer Clinical Trials
• Breast Cancer
• Breast Cancer - Surgery
• Breast Surgery

Administrative Appointments

• Chief of Breast Surgery, Section of Surgical Oncology (2005 - present)

Honors and Awards

• Protocol Chair Breast Cancer Local Recurrence Trial, NSABP (2006)
• Working Group Breast Committee, NSABP (2000)
• Awards Committee, Assoc Women Surgeons (2004)

Professional Education

Postdoctoral Advisees

Anne Kieryn

Graduate & Fellowship Program Affiliations

• Surgery

Current Research Interests

Clinical treatment trials in Breast Cancer, especially locally recurrent breast cancer. She is chair of multicenter national trial investigating the optimal systemic treatment for women who develop a local or regional recurrence of breast cancer after mastectomy or lumpectomy. Additinally, Dr. Wapnir is institutional Principal Investigator for National Surgical Adjuvant Breast and Bowel Project (NSABP). Her basic and preclinical research centers on exploring the activity of breast sodium-iodide transporter (NIS) in breast cancer. Translational research protocols elucidating the potential application of NIS-based therapies are ongoing.

Clinical Trials

• Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer Recruiting
• Factors Influencing Decision-Making About the Use of Chemoprevention in Women at Increased Risk for Breast Cancer Recruiting
• Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT Recruiting
• Radiation Therapy in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer Recruiting
• Radioactive Iodide (131I) Treatment of 124I PET/CT Detected Breast Cancers Recruiting

Publications

• The diagnostic value of nipple discharge cytology: Breast imaging complements predictive value of nipple discharge cytology. Kalu ON, Chow C, Wheeler A, Kong C, Wapnir I. J Surg Oncol. 2012
• Eusorbents and eusorption: a review of physiological events to therapeutic concepts. Wapnir RA, Wapnir I, Lifshitz F. J Am Coll Nutr. 2011; 30 (1): 1-10
• Integration and safety of fertility preservation in a breast cancer program. Westphal LM, Wapnir IL. Gynecol Oncol. 2011
• KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells. Beyer S, Lakshmanan A, Liu YY, Zhang X, Wapnir I, Smolenski A, Jhiang S. Endocrinology. 2011; 152 (3): 782-92
• Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS. Wapnir IL, Dignam JJ, Fisher B, Mamounas EP, Anderson SJ, Julian TB, Land SR, Margolese RG, Swain SM, Costantino JP, Wolmark N. J Natl Cancer Inst. 2011; 103 (6): 478-88