Joachim Hallmayer

Honors and Awards

• Section Editor, Current Psychiatry Reports - Nonschizophrenic Psychotic Disorders (2001)
• Temporary Member, Genome Study Section Center for Scientific Review (2001-2002)
• Editorial Board, Pscychiatric Genetics (1994)
• Young Investor Award, National Alliance for Research on Schizophrenia and Depression (1991)
• Fellow of the German Research Association, Deutsche Forschungsgemeinschaft (German Research Foundation) (1989)

Professional Education

Postdoctoral Advisees

Wendy Froehlich , Mina Hah

Graduate & Fellowship Program Affiliations

• Genetics
• Neurosciences

Research Interests

Principal Investigator
Infrastructure to facilitate discovery of autism genes
The purpose of this project is to facilitate the discovery of the genes that contribute autism by maintaining an infrastructure which research groups studying the genetics of autism can work collaboratively. This will be
accomplished through workshops, a Virtual Private Network, and access to a database that includes phenotype and genotype data from all participating groups.

Principal Investigator
A California Population-Based Twin Study of Autism
This will address several fundamental questions: (1) What is the heritability of autism (2) What is the contribution of genetic factors to variation in symptom dimensions? (3) Is there a continuum between the quantitative neurocognitive traits and clinical disorder? (4) What proportion of the variance in the neurocognitive traits is accounted for by genetic and non-genetic factors?

Co-Investigator
Center for Integrating Ethics in Genetics Research(Cho)
The goal of this project is to serve as a center of excellence in neurogenetics research, to develop a national model for bench, to bedside research ethics consultation, and to provide training opportunity in biomedical ethics.

Co-Investigator
Gene, Brain and Behavior in Turner Syndrome(Reiss)
The primary objective of this project is to use advanced, multi-modal magnetic resonance imaging (MRI) techniques, analyses of X chromosome parent-of-origin and cognitive-behavioral assessment to elucidate the effects of monosomy and X-linked imprinting on neurodevelopment and neural function in a large cohort of young girls with Turner syndrome, pre-estrogen replacement.

Project Director
Project F: Genomic Analysis in narcolepsy cataplexy
The goal of the project is to locate genes outside the HLA region that influence susceptibility to narcolepsy. In order to localize these genes we will carry out a linkage and association study...

Clinical Trials

• Intellectual Impairment in Women With Breast Cancer Not yet recruiting

Publications

• A genome-wide linkage and association scan reveals novel loci for autism. Weiss LA, Arking DE, Daly MJ, Chakravarti A. Nature. 2009; 461 (7265): 802-8
• Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. Fredericks CA, Drabant EM, Edge MD, Tillie JM, Hallmayer J, Ramel W, Kuo JR, Mackey S, Gross JJ, Dhabhar FS. Brain Behav Immun. 2009
• Twins with KBG Syndrome and Autism. Hah M, Lotspeich LJ, Phillips JM, Torres AD, Cleveland SC, Hallmayer JF. J Autism Dev Disord. 2009
• Bipolar disorder in the Bulgarian Gypsies: genetic heterogeneity in a young founder population. Kaneva R, Milanova V, Angelicheva D, MacGregor S, Kostov C, Vladimirova R, Aleksiev S, Angelova M, Stoyanova V, Loh A, Hallmayer J, Kalaydjieva L, Jablensky A. Am J Med Genet B Neuropsychiatr Genet. 2009; 150B (2): 191-201
• Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia. Chandler D, Dragovi? M, Cooper M, Badcock JC, Mullin BH, Faulkner D, Wilson SG, Hallmayer J, Howell S, Rock D, Palmer LJ, Kalaydjieva L, Jablensky A. Am J Med Genet B Neuropsychiatr Genet. 2009