Paul Buckmaster, DVM, PhD
Academic Appointments
- Professor, Comparative Medicine
- Member, Bio-X
- Professor, Neurology & Neurological Sciences
Key Documents
Contact Information
- Academic Offices
Personal Information Email
Professional Overview
Administrative Appointments
- Comparative Medicine Review Committee (RIRG-C) Study Section, NCRR, NIH (2008 - 2012)
- Research Council of the Professional Advisory Board, Epilepsy Foundation (2003 - present)
- Clinical Neuroplasticity and Neurotransmitter Study Section, NIH Center for Scientific Review (2004 - 2008)
Honors and Awards
- Career Award in the Biomedical Sciences, Burroughs Wellcome Fund (1996-2000)
Professional Education
| DVM: | University of California, Davis, Veterinary Medicine (1988) |
| PhD: | University of Washington, Physiology (1992) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
Temporal lobe epilepsy is common, frequently refractory to treatment, and devastating to those affected. Our long-term goal is to better understand the pathophysiological mechanisms of this disease so that rational and effective therapies can be developed. We use electrophysiological, molecular, and anatomical techniques to evaluate neuronal circuitry in normal and in epileptic brains.
Publications
- Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci. 2012; (4): 1183-96
- Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci. 2011; (6): 2337-47
- Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. J Comp Neurol. 2010; (5): 647-67
- Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy. J Neurosci. 2009; (24): 7846-56
- Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J Neurosci. 2009; (25): 8259-69
- Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy. J Neurosci. 2009; (45): 14247-56
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