David Feldman
Academic Appointments
- Professor Emeritus, Medicine - Endocrinology, Gerontology, & Metabolism
- Emeritus Faculty, Acad Council, Medicine - Endocrinology, Gerontology, & Metabolism
- Member, Stanford Cancer Institute
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 725-2910
Professional Overview
Honors and Awards
- Award for a Career of Outstanding Contributions to Vitamin D Research, Vitamin D Workshop (October 2009)
Internet Links
Scientific Focus
Current Research Interests
Steroid hormones act by binding to intracellular receptors that regulate the expression of specific genes in target cells. My group is studying a number of aspects that relate molecular and cellular events of hormone action at the receptor level to clinically relevant questions. Some of the current projects are as follows:
1. Investigation of the role of vitamin D as a differentiating and antiproliferative agent with the potential to affect malignancy, specifically to benefit breast and prostate cancer.
2. Studies of the metabolic effects of obesity to cause increased risk and worse prognosis in breast cancer in mouse models and in patients with breast cancer. Study of whether vitamin D can reduce the risk and/or improve the likelihood of a better outcome.
3. Study vitamin D action on cancer in cultured cells, in mouse models of cancer and in trials in patients with breast cancer.
4. Analysis of the endocrinologic and molecular mechanisms regulating vitamin D receptor expression and action thereby modulating target organ responsiveness to the actions of vitamin D and its analogs.
5. Elucidation of the molecular basis of hereditary vitamin D resistant rickets, a genetic disease due to mutations in the vitamin D receptor.
Clinical Trials
- Recruiting Vitamin D and Breast Cancer: Does Weight Make a Difference?
- Not Recruiting Calcitriol or Placebo in Men for Prostate Cancer Active Surveillance
- Not Recruiting A Phase II Trial of Calcitriol and Naproxen in Patients With Recurrent Prostate Cancer
- Not Recruiting Development of Vitamin D as a Therapy for Breast Cancer - Phase II
Publications
- Enteral calcium infusion used successfully as treatment for a patient with hereditary vitamin D resistant rickets (HVDRR) without alopecia: a novel mutation. Gene. 2013; (2): 554-9
- Successful long-term treatment of Cushing disease with mifepristone (RU486). Endocr Pract. 2012 Sep-Oct; (5): e114-20
- Combination of calcitriol and dietary soy exhibits enhanced anticancer activity and increased hypercalcemic toxicity in a mouse xenograft model of prostate cancer. Prostate. 2012; (15): 1628-37
- Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer. Endocrinology. 2012; (6): 2576-87
- Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention. J Steroid Biochem Mol Biol. 2012
- Genetic disorders and defects in vitamin D action. Rheum Dis Clin North Am. 2012; (1): 93-106
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