{"result":[{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://med.stanford.edu/profiles/cancer/researcher/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines."},{"lastName":"Chu","clinicalFocus":[{"focus":"Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4149&type=small&showNoImage","displayName":"Gilbert Chu","firstName":"Gilbert","href":"http://med.stanford.edu/profiles/cancer/researcher/Gilbert_Chu","researchInterest":"Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage."},{"lastName":"Jackson","clinicalFocus":[],"appointments":[{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Cancer Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4463&type=small&showNoImage","displayName":"Peter Jackson","firstName":"Peter","href":"http://med.stanford.edu/profiles/cancer/researcher/Peter_Jackson","researchInterest":"Cell cycle and cyclin control of DNA replication ."},{"lastName":"Wang","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4110&type=small&showNoImage","displayName":"Teresa Wang","firstName":"Teresa","href":"http://med.stanford.edu/profiles/cancer/researcher/Teresa_Wang","researchInterest":"The main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication."},{"lastName":"Davis","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4117&type=small&showNoImage","displayName":"Ronald Davis","firstName":"Ronald","href":"http://med.stanford.edu/profiles/cancer/researcher/Ronald_Davis","researchInterest":"We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion."},{"lastName":"Berg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Biochemistry"},{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"primaryAppointment":"Emeritus (Active) Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","displayName":"Paul Berg","firstName":"Paul","href":"http://med.stanford.edu/profiles/cancer/researcher/Paul_Berg","researchInterest":"For about 10 years until 2000, my lab\u0092s research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro"},{"lastName":"Pringle","clinicalFocus":[],"appointments":[{"appointment":"Professor,Genetics"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7022&type=small&showNoImage","displayName":"John R. Pringle","firstName":"John","href":"http://med.stanford.edu/profiles/cancer/researcher/John_Pringle","researchInterest":"Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis.  In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood."},{"lastName":"Tran","clinicalFocus":[],"appointments":[{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Member,Cancer Center","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8562&type=small&showNoImage","displayName":"Phuoc T. Tran","firstName":"Phuoc","href":"http://med.stanford.edu/profiles/cancer/researcher/Phuoc_Tran","researchInterest":""},{"lastName":"Driscoll","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8819&type=small&showNoImage","displayName":"Robert Driscoll","firstName":"Robert","href":"http://med.stanford.edu/profiles/cancer/researcher/Robert_Driscoll","researchInterest":""},{"lastName":"Hanawalt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5957&type=small&showNoImage","displayName":"Philip Hanawalt","firstName":"Philip","href":"http://med.stanford.edu/profiles/cancer/researcher/Philip_Hanawalt","researchInterest":"Hanawalt has been a productive researcher in the field of DNA repair since his pioneering discovery of repair replication in E. coli in 1963. He also first demonstrated repair replication in mycoplasmata and in a eukaryote and he has developed a number of important experimental approaches for studying repair, beginning with the BrdUrd density labeling method for resolving semiconservatively replicated DNA from parental DNA containing repair patches. Hanawalt\u0092s approach was used to validate the "},{"lastName":"Gozani","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6423&type=small&showNoImage","displayName":"Or Gozani","firstName":"Or","href":"http://med.stanford.edu/profiles/cancer/researcher/Or_Gozani","researchInterest":"We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease.  Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes.  We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions."},{"lastName":"Straight","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6006&type=small&showNoImage","displayName":"Aaron Straight","firstName":"Aaron","href":"http://med.stanford.edu/profiles/cancer/researcher/Aaron_Straight","researchInterest":"We study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis."},{"lastName":"Levy","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10527&type=small&showNoImage","displayName":"Dan Levy","firstName":"Dan","href":"http://med.stanford.edu/profiles/cancer/researcher/Dan_Levy","researchInterest":""},{"lastName":"Morrison","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Biology (School of Humanities and Sciences)"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14873&type=small&showNoImage","displayName":"Ashby Morrison","firstName":"Ashby","href":"http://med.stanford.edu/profiles/cancer/researcher/Ashby_Morrison","researchInterest":"Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity."},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","displayName":"Patrick O. Brown","firstName":"Patrick","href":"http://med.stanford.edu/profiles/cancer/researcher/Patrick_Brown","researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer."},{"lastName":"Hsu","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8699&type=small&showNoImage","displayName":"Jerry Hsu","firstName":"Jerry","href":"http://med.stanford.edu/profiles/cancer/researcher/Jerry_Hsu","researchInterest":""},{"lastName":"Chua","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Medicine - Endocrinology/Gerontology/Metab"},{"appointment":"Member,Cancer Center"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Medicine - Endocrinology/Gerontology/Metab","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6623&type=small&showNoImage","displayName":"Katrin Chua","firstName":"Katrin","href":"http://med.stanford.edu/profiles/cancer/researcher/Katrin_Chua","researchInterest":"Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals.  We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies.  In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress.  We have now begun to characterize the molecular mechanisms b"},{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://med.stanford.edu/profiles/cancer/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development."},{"lastName":"Ford","clinicalFocus":[{"focus":"Cancer Genetics"},{"focus":"Gastrointestinal Cancers - Genetics"},{"focus":"Gastrointestinal Cancers - Medical Oncology"},{"focus":"Breast Cancer - Genetics"},{"focus":"Ovarian Cancer - Genetics"},{"focus":"Medical Oncology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Associate Professor (By courtesy),Pediatrics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4066&type=small&showNoImage","displayName":"James Ford","firstName":"James","href":"http://med.stanford.edu/profiles/cancer/researcher/James_Ford","researchInterest":"Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNA\u000bdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/cancer/researcher/Amato_Giaccia","researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells."},{"lastName":"Cherry","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4249&type=small&showNoImage","displayName":"Mike Cherry","firstName":"JMichael","href":"http://med.stanford.edu/profiles/cancer/researcher/JMichael_Cherry","researchInterest":"The focus of my group is the application of bioinformatics to the collection and dissemination genetic, genomic and cellular  information. We abstracts the published results into our database, SGD. We explore the volumes of information that have been elucidated for the budding yeast S. cerevisiae.  My research is the applied use computers and databases: designing a resource to effectively provide biological information to the research community, and the development of the Gene Ontology."},{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://med.stanford.edu/profiles/cancer/researcher/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Nachury","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8391&type=small&showNoImage","displayName":"Maxence Nachury","firstName":"Maxence","href":"http://med.stanford.edu/profiles/cancer/researcher/Maxence_Nachury","researchInterest":"We study the primary cilium, a once-obscure cellular organelle recently \"re-discovered\" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is  to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways."},{"lastName":"Collins","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=10605&type=small&showNoImage","displayName":"Sean Collins","firstName":"Sean","href":"http://med.stanford.edu/profiles/cancer/researcher/Sean_Collins","researchInterest":""},{"lastName":"Lorch","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Structural Biology"}],"primaryAppointment":"Associate Professor (Research),Structural Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4116&type=small&showNoImage","displayName":"Yahli Lorch","firstName":"Yahli","href":"http://med.stanford.edu/profiles/cancer/researcher/Yahli_Lorch","researchInterest":""}]}