{"result":[{"lastName":"Chien","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4121&type=small&showNoImage","displayName":"Yueh-hsiu Chien","firstName":"Yueh-Hsiu","href":"http://med.stanford.edu/profiles/cancer/researcher/Yueh-Hsiu_Chien","researchInterest":"Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses."},{"lastName":"Fathman","clinicalFocus":[{"focus":"Immunology"},{"focus":"Immunology and Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4479&type=small&showNoImage","displayName":"C. Garrison Fathman","firstName":"C","href":"http://med.stanford.edu/profiles/cancer/researcher/C_Fathman","researchInterest":"My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity.   We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have idintified a gene (GRAIL) that seems to control T cell anergy and are defining the regulatory T cell core transcriptome.  Additional studies are on the mechanism of effect of anti-CD3 antibodies in therapy of T1D."},{"lastName":"Garcia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4370&type=small&showNoImage","displayName":"Chris Garcia","firstName":"Chris","href":"http://med.stanford.edu/profiles/cancer/researcher/Chris_Garcia","researchInterest":"Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology.  We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches."},{"lastName":"Engleman","clinicalFocus":[{"focus":"Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4490&type=small&showNoImage","displayName":"Edgar Engleman","firstName":"Edgar","href":"http://med.stanford.edu/profiles/cancer/researcher/Edgar_Engleman","researchInterest":"Dendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease."},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus (Active) Professor,Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","displayName":"Leonard Herzenberg","firstName":"Leonard","href":"http://med.stanford.edu/profiles/cancer/researcher/Leonard_Herzenberg","researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC)."},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor (Research),Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","displayName":"Leonore A. Herzenberg","firstName":"Leonore","href":"http://med.stanford.edu/profiles/cancer/researcher/Leonore_Herzenberg","researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays."},{"lastName":"Parnes","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","displayName":"Jane Parnes","firstName":"Jane","href":"http://med.stanford.edu/profiles/cancer/researcher/Jane_Parnes","researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease."},{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://med.stanford.edu/profiles/cancer/researcher/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Lee","clinicalFocus":[{"focus":"Hematology"},{"focus":"Leukemia - Hematology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Hematology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Medicine - Hematology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4564&type=small&showNoImage","displayName":"Peter P. Lee","firstName":"Peter","href":"http://med.stanford.edu/profiles/cancer/researcher/Peter_Lee","researchInterest":"Understanding the biology of cancer-T cell interactions."},{"lastName":"Levy","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor (Research),Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4307&type=small&showNoImage","displayName":"Shoshana Levy","firstName":"Shoshana","href":"http://med.stanford.edu/profiles/cancer/researcher/Shoshana_Levy","researchInterest":"Our research focuses on the mechanism of action of tetraspanins, an evolutionary conserved, widely expressed multi-gene family. We study a prototype, CD81, a molecule implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria."},{"lastName":"Ely","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9001&type=small&showNoImage","displayName":"Lauren Ely","firstName":"Lauren","href":"http://med.stanford.edu/profiles/cancer/researcher/Lauren_Ely","researchInterest":""},{"lastName":"Butcher","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4498&type=small&showNoImage","displayName":"Eugene Butcher","firstName":"Eugene","href":"http://med.stanford.edu/profiles/cancer/researcher/Eugene_Butcher","researchInterest":"Our interests include: \r\n1) The physiology and significance of lymphocyte homing in local and systemic immunity; \r\n2) biochemical and genetic studies of molecules that direct leukocyte recruitment; \r\n3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; \r\n4) vascular differentiation in normal and pathologic inflammatory states; \r\n5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs."},{"lastName":"Lewis","clinicalFocus":[{"focus":"Infectious Diseases, Pediatric"},{"focus":"Pediatric Infectious Disease"}],"appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor - Med Center Line,Pediatrics - Immunology & Transplant Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4439&type=small&showNoImage","displayName":"David B. Lewis","firstName":"David","href":"http://med.stanford.edu/profiles/cancer/researcher/David_Lewis","researchInterest":"My laboratory has two major research interests.  First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies.  Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines."},{"lastName":"Michie","clinicalFocus":[{"focus":"Anatomic Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4707&type=small&showNoImage","displayName":"Sara Michie","firstName":"Sara","href":"http://med.stanford.edu/profiles/cancer/researcher/Sara_Michie","researchInterest":"Lymphocyte/endothelial cell adhesion mechanisms involved in lymphocyte migration to sites of inflammation; regulation of expression of endothelial cell adhesion molecules."},{"lastName":"McDevitt","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Microbiology & Immunology"},{"appointment":"Emeritus Faculty, Acad Council,Microbiology & Immunology"},{"appointment":"Emeritus Faculty, Acad Council,Medicine"}],"primaryAppointment":"Emeritus (Active) Professor,Microbiology & Immunology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4597&type=small&showNoImage","displayName":"Hugh McDevitt","firstName":"Hugh","href":"http://med.stanford.edu/profiles/cancer/researcher/Hugh_McDevitt","researchInterest":"The structure of class II major histocompatibility complex molecules, their role in antigen presentation, and in the immune response in health and disease with emphasis on type 1 diabetes and rheumatoid arthritis; the role of lymphokines (tumor necrosis factor alpha, lymphotoxin) in autoimmunity."},{"lastName":"Kasson","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemistry"}],"primaryAppointment":"Postdoctoral Research fellow, Chemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9965&type=small&showNoImage","displayName":"Peter Kasson","firstName":"Peter","href":"http://med.stanford.edu/profiles/cancer/researcher/Peter_Kasson","researchInterest":""},{"lastName":"Strober","clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4152&type=small&showNoImage","displayName":"Samuel Strober","firstName":"Samuel","href":"http://med.stanford.edu/profiles/cancer/researcher/Samuel_Strober","researchInterest":"Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation."},{"lastName":"Vrljic","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8903&type=small&showNoImage","displayName":"Marija Vrljic","firstName":"Marija","href":"http://med.stanford.edu/profiles/cancer/researcher/Marija_Vrljic","researchInterest":""},{"lastName":"Levy","clinicalFocus":[{"focus":"Lymphoma "},{"focus":"Non-Hodgkin's Lymphoma"},{"focus":"Non-Hodgkin's Lymphoma - Medical Oncology"},{"focus":"Burkitt's Lymphoma"},{"focus":"Burkitt's Lymphoma - Medical Oncology"},{"focus":"Hodgkin's Disease"},{"focus":"Hodgkin's Disease - Medical Oncology"},{"focus":"Burkitt's Lymphoma - Hematology"},{"focus":"Hodgkin's Disease - Hematology"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"},{"focus":"Non-Hodgkin's Lymphoma - Hematology"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4608&type=small&showNoImage","displayName":"Ronald Levy, MD","firstName":"Ronald","href":"http://med.stanford.edu/profiles/cancer/researcher/Ronald_Levy","researchInterest":"Clinical Interests: lymphoma. Research Interests: Immunology and molecular biology of lymphoid malignancy; molecular vaccines for cancer."},{"lastName":"Weissman","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology - Stem Cell Institute"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor (By courtesy),Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology - Stem Cell Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4605&type=small&showNoImage","displayName":"Irving Weissman","firstName":"Irving","href":"http://med.stanford.edu/profiles/cancer/researcher/Irving_Weissman","researchInterest":"Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis."},{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://med.stanford.edu/profiles/cancer/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development."},{"lastName":"Cochran","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Bioengineering"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Bioengineering","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6393&type=small&showNoImage","displayName":"Jennifer R. Cochran","firstName":"Jennifer","href":"http://med.stanford.edu/profiles/cancer/researcher/Jennifer_Cochran","researchInterest":"Molecular Bioengineering, Protein Biochemistry and Biotechnology, Cell and Tissue Engineering, Molecular Imaging"},{"lastName":"Steinman","clinicalFocus":[{"focus":"Neurology"},{"focus":"Neurology, Pediatric"},{"focus":"Multiple Sclerosis, Myasthenia Gravis, Immune Disorders"}],"appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor,Pediatrics"},{"appointment":"Professor (By courtesy),Genetics"}],"primaryAppointment":"Professor,Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3784&type=small&showNoImage","displayName":"Lawrence Steinman","firstName":"Lawrence","href":"http://med.stanford.edu/profiles/cancer/researcher/Lawrence_Steinman","researchInterest":"Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis.  We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab.  We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids.  We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis."},{"lastName":"Rouse","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Professor - Med Center Line,Pathology"}],"primaryAppointment":"Professor - Med Center Line,Pathology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4491&type=small&showNoImage","displayName":"Robert V Rouse","firstName":"Robert","href":"http://med.stanford.edu/profiles/cancer/researcher/Robert_Rouse","researchInterest":"My recent research efforts are currently focused in the field of applications of immunohistology to the diagnosis of human neoplasms. This work is predominantly aimed at characterizing markers for the identification of non-lymphoid neoplasms and at establishing criteria for their evaluation in diagnostic situations."},{"lastName":"Quertermous","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","displayName":"Thomas Quertermous, MD","firstName":"Thomas","href":"http://med.stanford.edu/profiles/cancer/researcher/Thomas_Quertermous","researchInterest":"Understanding genetic basis of cardiovascular function and disease."}]}