{"result":[{"researchInterest":"Our laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3984&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Lawrence_Recht","appointments":[{"appointment":"Professor - Med Center Line,Neurology & Neurological Sciences"},{"appointment":"Professor - Med Center Line (By courtesy),Neurosurgery"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Neurology"}],"firstName":"Lawrence","primaryAppointment":"Professor - Med Center Line,Neurology & Neurological Sciences","displayName":"Lawrence Recht","lastName":"Recht"},{"researchInterest":"Microsurgical treatment of tumors of the brain, spinal cord, pituitary gland and skull base; \r\nRadiosurgery of tumors;\r\nMolecular biology of brain tumors.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4394&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Griffith_Harsh","appointments":[{"appointment":"Professor - Med Center Line,Neurosurgery"},{"appointment":"Professor - Med Center Line (By courtesy),Otolaryngology (Head and Neck Surgery)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Acoustic Neuroma "},{"focus":"Acoustic Neuroma - Head and Neck Surgery"},{"focus":"Brain / Central Nervous System Tumors"},{"focus":"Brain / Central Nervous System Tumors - Neuro Oncology"},{"focus":"Brain / Central Nervous System Tumors - Neurosurgery"},{"focus":"Germ Cell Tumors"},{"focus":"Germ Cell Tumors - Neurosurgery"},{"focus":"Leptommeningeal Disease"},{"focus":"Leptommeningeal Disease - Neurosurgery"},{"focus":"Multiple Endocrine Neoplasias"},{"focus":"Multiple Endocrine Neoplasias - Neurosurgery"},{"focus":"Neuroendocrine"},{"focus":"Neuroendocrine - Surgery"},{"focus":"Neurological Surgery"},{"focus":"Neurosurgery"},{"focus":"Pituitary Adenomas"},{"focus":"Pituitary Adenomas - Neurosurgery"},{"focus":"Skull Base Tumors "},{"focus":"Skull Base Tumors - Head and Neck Surgery"},{"focus":"Skull Base Tumors - Neurosurgery"},{"focus":"Spinal Cancer"},{"focus":"Spinal Cancer - Neurosurgery"},{"focus":"Spinal Cancer - Surgery"}],"firstName":"Griffith","primaryAppointment":"Professor - Med Center Line,Neurosurgery","displayName":"Griffith Harsh","lastName":"Harsh"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6767&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Terri_Haddix","appointments":[{"appointment":"Clinical Assistant Professor,Pathology"}],"clinicalFocus":[{"focus":"Pathology"},{"focus":"Anatomic/Clinical Pathology"}],"firstName":"Terri","primaryAppointment":"Clinical Assistant Professor,Pathology","displayName":"Terri Haddix","lastName":"Haddix"},{"researchInterest":"My research focus is on tumor angiogenesis.  We are working on the contributions of progenitor cells in the formation of tumor vessels. We are particularly interested in a population of cells that are derived from putative \"hemangioblast\", and their role in vasculogenesis.  We sumrise that these cells have a close association with cancer stem cells, and are essential in promoting tumor expansion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4421&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Victor_Tse","appointments":[{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Victor","primaryAppointment":"Member,Bio-X","displayName":"Victor Tse, MD PhD","lastName":"Tse"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6036&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Michael_Edwards","appointments":[{"appointment":"Professor - Med Center Line,Neurosurgery"},{"appointment":"Professor - Med Center Line (By courtesy),Pediatrics"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Neurological Surgery"},{"focus":"Neurosurgery"},{"focus":"Neurosurgery, Pediatric"}],"firstName":"Michael","primaryAppointment":"Professor - Med Center Line,Neurosurgery","displayName":"Michael S. B. Edwards M.D.","lastName":"Edwards"},{"researchInterest":"We are interested in understanding how neural stem cells balance their self-renewal and differentiation and how deregulation of this process can result in brain tumor. We are also interested in mechanisms of neurodegeneration in Alzheimer\u0092s and Parkinson\u0092s diseases. We are using both Drosophila and mammalian models to address these fundamental questions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3976&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bingwei_Lu","appointments":[{"appointment":"Assistant Professor,Pathology"}],"clinicalFocus":[],"firstName":"Bingwei","primaryAppointment":"Assistant Professor,Pathology","displayName":"Bingwei Lu","lastName":"Lu"},{"researchInterest":"Clinical neuro-oncology: My research explores the epidemiology, natural history, and disease patterns of brain tumors in childhood, as well as prospective clinical trials for treating these neoplasms.  Research interests also include neurologic effects of cancer and its therapies,  and childhood headaches.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4681&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Paul_Fisher","appointments":[{"appointment":"Professor - Med Center Line,Neurology & Neurological Sciences"},{"appointment":"Professor - Med Center Line,Pediatrics"},{"appointment":"Professor - Med Center Line (By courtesy),Neurosurgery"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Neurology - Child Neurology"},{"focus":"Neuro-Oncology"},{"focus":"Neurology"}],"firstName":"Paul","primaryAppointment":"Professor - Med Center Line,Neurology & Neurological Sciences","displayName":"Paul Graham Fisher","lastName":"Fisher"},{"researchInterest":"I have clinical research interests in the surgical treatment of epilepsy.  I am also interested in new developments in the treatment of craniosynostosis a congenital abnormality of infant's skulls","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4128&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Lawrence_Shuer","appointments":[{"appointment":"Professor - Med Center Line,Neurosurgery"}],"clinicalFocus":[{"focus":"Neurological Surgery"},{"focus":"Neurosurgery"},{"focus":"Neurosurgery, Pediatric"}],"firstName":"Lawrence","primaryAppointment":"Professor - Med Center Line,Neurosurgery","displayName":"Lawrence Shuer","lastName":"Shuer"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13527&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Bret_Mobley","appointments":[{"appointment":"Instructor,Pathology"}],"clinicalFocus":[{"focus":"Anatomic/Clinical Pathology"}],"firstName":"Bret","primaryAppointment":"Instructor,Pathology","displayName":"Bret Mobley","lastName":"Mobley"},{"researchInterest":"Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3851&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Laura_Attardi","appointments":[{"appointment":"Associate Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Associate Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Laura","primaryAppointment":"Associate Professor,Radiation Oncology - Radiation Biology","displayName":"Laura Attardi","lastName":"Attardi"},{"researchInterest":"Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4165&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Matthew_Scott","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Matthew","primaryAppointment":"Professor,Developmental Biology","displayName":"Matthew Scott","lastName":"Scott"},{"researchInterest":"Use of genetic and molecular tools to dissect immune and inflammatory pathways in Alzheimer's and neurodegeneration.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3929&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Tony_Wyss-Coray","appointments":[{"appointment":"Associate Professor (Research),Neurology & Neurological Sciences"}],"clinicalFocus":[],"firstName":"Tony","primaryAppointment":"Associate Professor (Research),Neurology & Neurological Sciences","displayName":"Tony Wyss-Coray","lastName":"Wyss-Coray"},{"researchInterest":"Clinical interests include Alzheimer\u0092s disease and Huntington\u0092s disease and the development of effective therapeutics for these disorders. Laboratory interests encompass the elucidation of signaling mechanisms relevant to neurodegenerative disorders and the development of novel small molecule approaches for the treatment of neurodegenerative and other neurological disorders.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7249&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Frank_Longo","appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"clinicalFocus":[{"focus":"Neurology"},{"focus":"Alzheimer's Disease"},{"focus":"Huntington Disease"}],"firstName":"Frank","primaryAppointment":"Professor,Neurology & Neurological Sciences","displayName":"Frank M. Longo, M.D., Ph.D.","lastName":"Longo"},{"researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Isabella_Graef","appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Isabella","primaryAppointment":"Assistant Professor,Pathology","displayName":"Isabella Graef","lastName":"Graef"},{"researchInterest":"We are dedicated to develop multifunctional molecular probes for multimodality imaging and bioconjugates for target-specific drug delivery. The research tools include bioconjugation chemistry, radiochemistry (PET/SPECT), nanotechnology, and stem cell biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6470&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Xiaoyuan_Chen","appointments":[{"appointment":"Associate Professor (Research),Radiology - Diagnostic Radiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Xiaoyuan","primaryAppointment":"Associate Professor (Research),Radiology - Diagnostic Radiology","displayName":"Xiaoyuan (Shawn) Chen","lastName":"Chen"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9160&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Stephan_Gehrke","appointments":[{"appointment":"Postdoctoral Research fellow, Pathology"}],"clinicalFocus":[],"firstName":"Stephan","primaryAppointment":"Postdoctoral Research fellow, Pathology","displayName":"Stephan Gehrke","lastName":"Gehrke"},{"researchInterest":"My lab focuses on cancer stem cell biology and its implications for cancer therapy. We are interested in developing a deeper molecular understanding of cancer stem cells, including identifying pathways and genes important for proliferation and self renewal. We also study these processes in normal adult stem cells in order to identify differences that could be exploited therapeutically. The goal of our studies is the development of novel therapeutic strategies for eliminating cancer stem cells.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9248&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Maximilian_Diehn","appointments":[{"appointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy"}],"clinicalFocus":[],"firstName":"Maximilian","primaryAppointment":"Acting Assistant Professor,Radiation Oncology - Radiation Therapy","displayName":"Maximilian Diehn, M.D., Ph.D.","lastName":"Diehn"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6718&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Samira_Guccione","appointments":[{"appointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Samira","primaryAppointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology","displayName":"Samira Guccione","lastName":"Guccione"},{"researchInterest":"My laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5931&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Dean_Felsher","appointments":[{"appointment":"Associate Professor,Medicine - Oncology"},{"appointment":"Associate Professor,Pathology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hodgkin's Disease"},{"focus":"Hodgkin's Disease - Hematology"},{"focus":"Hodgkin's Disease - Medical Oncology"},{"focus":"Lymphoma "},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"firstName":"Dean","primaryAppointment":"Associate Professor,Medicine - Oncology","displayName":"Dean W. Felsher","lastName":"Felsher"},{"researchInterest":"My research interests involve the epidemiology, treatment and diagnosis of pediatric and young adult brain tumors.  I am also interested in long-term neurologic effects and designing clinical trials to treat brain and spinal cord tumors.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8193&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Sonia_Partap","appointments":[{"appointment":"Instructor,Neurology & Neurological Sciences"}],"clinicalFocus":[{"focus":"Neurology"},{"focus":"Neurology - Child Neurology"}],"firstName":"Sonia","primaryAppointment":"Instructor,Neurology & Neurological Sciences","displayName":"Sonia Partap","lastName":"Partap"},{"researchInterest":"Molecular and cellular mechanisms that control muscle and neuronal growth; stem cell biology, differentiation, and tumorigenicity. Regulating stem cell fate in vitro and in vivo. Stem cell therapies. Hematopoietic and muscle stem cells. Characterizing and bioengineering stem cell niches. Nuclear reprogramming. Muscle development and disease. Drug delivery. Tracking cell behavior in vitro and in vivo. Understanding tissue degeneration and regeneration.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4517&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Helen_Blau","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Helen","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Helen M. Blau","lastName":"Blau"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9743&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Qizhen_Cao","appointments":[{"appointment":"Postdoctoral Research fellow, Radiology"}],"clinicalFocus":[],"firstName":"Qizhen","primaryAppointment":"Postdoctoral Research fellow, Radiology","displayName":"Qizhen Cao","lastName":"Cao"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9630&type=small&showNoImage","href":"http://med.stanford.edu/profiles/James_Olzmann","appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"clinicalFocus":[],"firstName":"James","primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","displayName":"James Olzmann","lastName":"Olzmann"},{"researchInterest":"Genetic and molecular basis of respiratory system  development, maintenance, and disease in Drosophila, mouse, and human","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4120&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Mark_Krasnow","appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Biochemistry","displayName":"Mark Krasnow","lastName":"Krasnow"},{"researchInterest":"Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt,  using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4280&type=small&showNoImage","href":"http://med.stanford.edu/profiles/Roeland_Nusse","appointments":[{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Roeland","primaryAppointment":"Professor,Developmental Biology","displayName":"Roeland Nusse","lastName":"Nusse"}]}