Paul Wender
Publication Details
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Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.
Bioorg Med Chem Lett. 1999; (12): 1687-90
Designed bryostatin analogues are assayed for binding affinity to individual cysteine rich domains of several protein kinase C (PKC) isozymes. These analogues exhibit significant selectivity for the PKCdelta-C1B peptide in terms of absolute affinity and the PKCdelta-C1A peptide in terms of relative affinity when compared to phorbol-12,13-dibutyrate.
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