Zhen Cheng
Publication Details
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Macrocyclic chelator assembled RGD multimers for tumor targeting.
Bioorg Med Chem Lett. 2011; (11): 3423-6
Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability.
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