Sandip Biswal, MD
Publication Details
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Continuous infusion of UHMWPE particles induces increased bone macrophages and osteolysis.
Clin Orthop Relat Res. 2011; (1): 113-22
Aseptic loosening and periprosthetic osteolysis resulting from wear debris are major complications of total joint arthroplasty. Monocyte/macrophages are the key cells related to osteolysis at the bone-implant interface of joint arthroplasties. Whether the monocyte/macrophages found at the implant interface in the presence of polyethylene particles are locally or systemically derived is unknown.
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