John Ioannidis
Publication Details
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Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials.
J Clin Epidemiol. 2005; (6): 543-9
Divergent results on the same scientific question generate controversy. We hypothesized that controversial data are attractive to investigators and editors, and thus the most extreme, opposite results would appear very early rather than late, as data accumulate, provided data can be generated rapidly.
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Trial Administration