Geoffrey Gurtner
Publication Details
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Using genetically modified microvascular free flaps to deliver local cancer immunotherapy with minimal systemic toxicity.
Plast Reconstr Surg. 2008; (5): 1541-53
Clinical use of cancer gene therapy has been prevented by the inability to deliver high levels of local transgene expression with acceptable host toxicity. The authors' laboratory has developed an ex vivo technique to genetically modify free flaps to deliver immunotherapy locally without systemic toxicity.
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