David Spiegel
Publication Details
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Diurnal cortisol rhythm as a predictor of breast cancer survival.
J Natl Cancer Inst. 2000; (12): 994-1000
: Abnormal circadian rhythms have been observed in patients with cancer, but the prognostic value of such alterations has not been confirmed. We examined the association between diurnal variation of salivary cortisol in patients with metastatic breast cancer and subsequent survival. We explored relationships between cortisol rhythms, circulating natural killer (NK) cell counts and activity, prognostic indicators, medical treatment, and psychosocial variables.
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