Cancer Institute– A national cancer institute
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Amato J. Giaccia

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Publication Details

  • The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.

    Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT. PLoS One. 2010; 5 (3): e9633

    Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function. Here, we use genetic approaches to systematically investigate the function of the RGD domain in different OPN isoforms on tumor progression and metastasis for 2 different solid tumor models.

    PubMedID: 20224789

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