Suzanne Pfeffer
Publication Details
-
Targeting Rab GTPases to distinct membrane compartments.
Nat Rev Mol Cell Biol. 2004; (11): 886-96
Rab GTPases are key to membrane-trafficking events in eukaryotic cells, and human cells contain more than 60 Rab proteins that are localized to distinct compartments. The recent determination of the structure of a monoprenylated Rab GTPase bound to GDP-dissociation inhibitor provides new molecular details that are relevant to models of Rab delivery. The further discovery of an integral membrane protein that can dissociate prenylated Rab proteins from GDP-dissociation inhibitor gives new insights into the mechanisms of Rab localization.
Help
Trial Administration