Publication Details

Didanosine resistance in HIV-infected patients switched from zidovudine to didanosine monotherapy.

Kozal MJ, Kroodsma K, Winters MA, Shafer RW, Efron B, Katzenstein DA, Merigan TC. Ann Intern Med. 1994; 121 (4): 263-8

To determine the frequency and pattern of development of specific drug resistance mutations for human immunodeficiency virus (HIV) reverse transcriptase in patients switched from zidovudine to didanosine therapy and to examine the relation of the didanosine resistance mutation at codon 74 of the HIV reverse-transcriptase gene to CD4+ T-cell changes and virus burden.

PubMedID: 7518658