Ronald Levy, MD
Publication Details
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Antitumor immunity after vaccination with B lymphoma cells overexpressing a triad of costimulatory molecules.
J Natl Cancer Inst. 2003; (7): 548-55
The costimulatory molecules B7-1, intercellular adhesion molecule-1 (ICAM-1), and leukocyte function-associated antigen-3 (LFA-3) play pivotal roles in the activation of T cells. We investigated whether in vivo vaccination with lymphoma cells infected with a recombinant, nonreplicating fowlpox (FP) virus encoding this triad of costimulatory molecules (TRICOM) could stimulate lymphoma-specific immunity.
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