Donna Peehl, PhD
Publication Details
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Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts.
Prostate. 2009; (9): 991-1000
Cancer-associated stroma contributes to the malignant behavior of adenocarcinomas of the prostate and other organs. CD90 is a marker of mesenchymal stem cells (MSCs) and its expression is higher in prostate cancer stroma compared to normal tissue. Cultured prostate cancer-associated fibroblasts (CAFs) expressing high versus low levels of CD90 were analyzed for an MSC-like or tumor-promoting phenotype.
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