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Ling Oei

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Publication Details

  • The effect of thiazide and loop diuretics on urinary levels of free deoxypyridinoline: an osteoclastic bone-resorption marker.

    Ruiter R, Oei L, Visser LE, Peltenburg HG, Hofman A, Zillikens MC, Uitterlinden AG, Rivadeneira F, Stricker BH. J Clin Pharm Ther. 2013; 38 (3): 225-9

    Diuretics can cause changes in calcium levels due to renal effects. Moreover, calcium levels can also vary as a result of changes in intestinal absorption and in the activity of osteoclastic cells. A marker of osteoclastic bone-resorption activity is the level of urinary free deoxypyridinoline (FDP). Deoxypyridinoline (DP) acts as a cross-link between adjacent collagen chains to provide structural rigidity. Our aim was to investigate the association between use of thiazides and loop diuretics and urinary levels FDP.

    PubMedID: 23442167

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