Cancer Institute– A national cancer institute
designated cancer center

Sanjiv Sam Gambhir, MD, PhD

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Publication Details

  • Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.

    Cai W, Shin DW, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X. Nano Lett. 2006; 6 (4): 669-76

    We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

    PubMedID: 16608262

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