Sanjiv Sam Gambhir, MD, PhD
Publication Details
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Molecular imaging of phosphorylation events for drug development.
Mol Imaging Biol. 2009 May-Jun; (3): 144-58
Protein phosphorylation mediated by protein kinases controls numerous cellular processes. A genetically encoded, generalizable split firefly luciferase (FL)-assisted complementation system was developed for noninvasive monitoring phosphorylation events and efficacies of kinase inhibitors in cell culture and in small living subjects by optical bioluminescence imaging.
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